Expression of TBXT (T, Brachyury) in the primitive streak

Stable Identifier
R-HSA-452331
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Expression of TBXT (T, Brachyury) in the primitive streak
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The TBXT (T, Brachyury) gene is transcribed to yield mRNA and the mRNA is translated to yield protein. During early gastrulation, TBXT is expressed in cells in the primitive streak and in mesodermal cells near the primitive streak (inferred from the mouse homolog, inferred from the non-human primate Macaca fascicularis in Nakamura et al. 2016, Sasaki et al. 2016). After node formation, TBXT is expressed in the node and notochord and at later stages in the tailbud region. Expression of TBXT is required for initiating expression of posterior mesoderm gene programs (inferred from mouse homologs). Pluripotency factors are involved in the regulation of factors regulating gastrulation and mesoderm and definitive endoderm cell fate specification. In particular, OCT4 has been suggested to be involved in mesoderm induction and regulation of TBXT (Babaie et al. 2007, Funa et al. 2015, and inferred from mouse homologs). During gastrulation, WNT signaling activates expression of TBXT via LEF1 or TCF7 and beta catenin (CTNNB1) (inferred from mouse homologs). BMP4 also activates TBXT (Lu et al. 2008, Purpura et al. 2008, Zhang et al. 2008). TBPL2 (TRF3) binds the TATA-box during transcription in mesendoderm (Liang et al. 2020).
Literature References
PubMed ID Title Journal Year
18042803 Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells

Zhang, P, Li, J, Tan, Z, Wang, C, Liu, T, Chen, L, Yong, J, Jiang, W, Sun, X, Du, L, Ding, M, Deng, H

Blood 2008
18550259 Analysis of the temporal and concentration-dependent effects of BMP-4, VEGF, and TPO on development of embryonic stem cell-derived mesoderm and blood progenitors in a defined, serum-free media

Purpura, KA, Morin, J, Zandstra, PW

Exp Hematol 2008
32448362 TATA box-binding protein-related factor 3 drives the mesendoderm specification of human embryonic stem cells by globally interacting with the TATA box of key mesendodermal genes

Liang, H, Zhang, P, Bai, HJ, Huang, J, Yang, HT

Stem Cell Res Ther 2020
17068183 Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells

Babaie, Y, Herwig, R, Greber, B, Brink, TC, Wruck, W, Groth, D, Lehrach, H, Burdon, T, Adjaye, J

Stem Cells 2007
18729794 Robust generation of hemangioblastic progenitors from human embryonic stem cells

Lu, SJ, Luo, C, Holton, K, Feng, Q, Ivanova, Y, Lanza, R

Regen Med 2008
25921273 β-Catenin Regulates Primitive Streak Induction through Collaborative Interactions with SMAD2/SMAD3 and OCT4

Funa, NS, Schachter, KA, Lerdrup, M, Ekberg, J, Hess, K, Dietrich, N, Honoré, C, Hansen, K, Semb, H

Cell Stem Cell 2015
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
POU5F1 [nucleoplasm] (Homo sapiens)
Positively by
Regulator
LEF1,TCF7:CTNNB1:NANOG:TBPL2:TBXT gene [nucleoplasm] (Homo sapiens)
Regulator
BMP4 dimer [extracellular region] (Homo sapiens)
Inferred From
Expression of T (Tbxt) in the primitive streak (Mus musculus)
Authored
May, B  (2010-11-12)
Reviewed
Tam, PPL  (2022-05-08)
Probst, S  (2022-07-18)
Zissel, L  (2022-07-18)
Salehin, N  (2022-05-08)
Created
May, B  (2010-01-16)
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