Reactome | Expression of T (Tbxt) in the primitive streak

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Expression of T (Tbxt) in the primitive streak Show undefined attributes

authored	[InstanceEdit:9754188] May, Bruce, 2021-09-22
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9754277] May, Bruce, 2021-09-23
dbId	9754300
displayName	Expression of T (Tbxt) in the primitive streak
edited	[InstanceEdit:9754188] May, Bruce, 2021-09-22
input	[EntityWithAccessionedSequence:R-MMU-9754278] Tbxt gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9754257] Brachyury is a target gene of the Wnt/beta-catenin signaling pathway [LiteratureReference:9754249] T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification [LiteratureReference:9757306] Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation [LiteratureReference:9757596] Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo [LiteratureReference:9761134] Expression pattern of the Brachyury gene in whole-mount TWis/TWis mutant embryos [LiteratureReference:9761136] Immunohistochemical analysis of the Brachyury protein in wild-type and mutant mouse embryos [LiteratureReference:9794959] Pluripotency factors in embryonic stem cells regulate differentiation into germ layers [LiteratureReference:9794956] Charting Brachyury-mediated developmental pathways during early mouse embryogenesis [LiteratureReference:9754504] Eomes and Brachyury control pluripotency exit and germ-layer segregation by changing the chromatin state
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Expression of T (Tbxt) in the primitive streak
orthologousEvent	[BlackBoxEvent:R-HSA-452331] Expression of TBXT (T, Brachyury) in the primitive streak - Homo sapiens
output	[EntityWithAccessionedSequence:R-MMU-9733724] Tbxt [nucleoplasm]
regulatedBy	[PositiveGeneExpressionRegulation:9754292] Positive gene expression regulation by 'Lef1,Tcf7:Ctnnb1:Tp63:Tbpl2:T gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9754264] Positive gene expression regulation by 'Bmp4 dimer [extracellular region]'
regulationReference	[RegulationReference:9754243] Positive gene expression regulation by 'Bmp4 [extracellular region]' Bmp signaling maintains a mesoderm progenitor cell state in the mouse tailbud [RegulationReference:9754290] Positive gene expression regulation by 'Lef1,Tcf7:Ctnnb1:Tp63:Tbpl2:T gene [nucleoplasm]' Lack of beta-catenin affects mouse development at gastrulation
releaseDate	2022-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9773645] Tam, Patrick P L, 2022-05-08 [InstanceEdit:9796182] Salehin, Nazmus, 2022-05-08 [InstanceEdit:9794593] Probst, Simone, 2022-07-18 [InstanceEdit:9796183] Zissel, Lea, 2022-07-18
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-9754300
summation	[Summation:9754513] The Tbxt (T, Brachyury) gene is transcribed to yield mRNA an...
updateTrackers	[UpdateTracker:9846955] Update Tracker - [BlackBoxEvent:9754300] Expression of T (Tbxt) in the primitive streak - v82:[add_removeLiteratureReference, modifyText]

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[UpdateTracker:9846955] Update Tracker - [BlackBoxEvent:9754300] Expression of T (Tbxt) in the primitive streak - v82:[add_removeLiteratureReference, modifyText]

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