Reactome | hp-IRAK1,hp-IRAK4 bind Pellino1,2,3

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hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 Show undefined attributes

authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:450687] Jupe, S, 2009-12-17
dbId	450690
displayName	hp-IRAK1,hp-IRAK4 bind Pellino1,2,3
edited	[InstanceEdit:744683] Jupe, S, 2010-05-17
eventOf	[Pathway:R-HSA-9020702] Interleukin-1 signaling - Homo sapiens
input	[DefinedSet:R-HSA-450810] p-2S,S376,T,T209,T387-IRAK1, IRAK4 [cytosol] 2 × [DefinedSet:R-HSA-450814] Pellino 1,2,3 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:450692] The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1 [LiteratureReference:450818] Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex [LiteratureReference:450804] Characterization of Pellino2, a substrate of IRAK1 and IRAK4 [LiteratureReference:450820] Pellino3 is a novel upstream regulator of p38 MAPK and activates CREB in a p38-dependent manner [LiteratureReference:450816] Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	hp-IRAK1,hp-IRAK4 bind Pellino1,2,3
orthologousEvent	[Reaction:R-BTA-450690] hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 - Bos taurus [Reaction:R-CEL-450690] hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 - Caenorhabditis elegans [Reaction:R-DME-450690] hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 - Drosophila melanogaster [Reaction:R-DRE-450690] hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 - Danio rerio [Reaction:R-SSC-450690] hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 - Sus scrofa [Reaction:R-CFA-450690] hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 - Canis familiaris [Reaction:R-RNO-450690] hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 - Rattus norvegicus [Reaction:R-MMU-450690] hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 - Mus musculus
output	[DefinedSet:R-HSA-451413] hp-IRAK1:Pellino, IRAK4:Pellino [cytosol]
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:744680] Pinteaux, E, 2010-05-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-450690
summation	[Summation:450811] IRAK1 and 4 interact with Pellino-1 (Jiang et al. 2003), 2 (...

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[Pathway:R-HSA-9020702] Interleukin-1 signaling