hp-IRAK1,hp-IRAK4 bind Pellino1,2,3

Stable Identifier
R-HSA-450690
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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hp-IRAK1,hp-IRAK4 bind Pellino1,2,3
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IRAK1 and 4 interact with Pellino-1 (Jiang et al. 2003), 2 (Strellow et al. 2003) and 3 (Butler et al. 2005, 2007). Pellinos may act as scaffolding proteins, bringing signaling complexes into proximity. They are E3 ubiquitin ligases capable of ubiquitinating IRAK1, believed to mediate IL-1-stimulated formation of K63-polyubiquitinated IRAK1 in cells.

Though not clearly demonstrated and therefore not shown here, the current models of IRAK1 involvement suggest it would be within a complex including TRAF6.
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Orthologous Events
hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Bos taurus)
hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Caenorhabditis elegans)
hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Canis familiaris)
hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Drosophila melanogaster)
hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Mus musculus)
hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Rattus norvegicus)
hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Sus scrofa)
Authored
Ray, KP  (2010-05-17)
Reviewed
Pinteaux, E  (2010-05-17)
Created
Jupe, S  (2009-12-17)
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