IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F

Stable Identifier
R-HSA-447246
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F
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The Interleukin-17 receptor A/C complex is a dimer of Interleukin-17 receptor A (IL17RA) and Interleukin-17 receptor C (IL17RC). It binds interleukin-17A (IL17A) dimers, IL17F dimers and IL17A:IL17F heterodimers (IL17A:IL17F) (Yao et al. 1995, Toy et al. 2006). IL17A and IL17F homodimers tend to disfavor binding of a second molecule of IL17RA to the receptor/ligand complex (Liu et al. 2013). Engagement of IL17RA or IL17RC by IL17A or IL17F brings about an allosteric 'preference' for the second receptor-binding site to engage a different receptor to form a heterodimeric receptor complex (Ely et al. 2003) This is a Black Box event because the order of receptor binding is unclear.

Secreted SARS-CoV-2 ORF8 (8) binds to IL17RA and activates IL17 signaling pathway leading to an increased secretion of cytokines/chemokines thus contributing to cytokine storm during SARS-CoV-2 infection (Lin X et al. 2021).

Literature References
PubMed ID Title Journal Year
16785495 Cutting edge: interleukin 17 signals through a heteromeric receptor complex

Toy, D, Kugler, D, Wolfson, M, Vanden Bos, T, Gurgel, J, Derry, J, Tocker, J, Peschon, J

J Immunol 2006
16397230 Interleukin-17 receptor-like gene is a novel antiapoptotic gene highly expressed in androgen-independent prostate cancer

You, Z, Shi, XB, DuRaine, G, Haudenschild, D, Tepper, CG, Lo, SH, Gandour-Edwards, R, de Vere White, RW, Reddi, AH

Cancer Res 2006
8777726 Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor

Yao, Z, Fanslow, WC, Seldin, MF, Rousseau, AM, Painter, SL, Comeau, MR, Cohen, JI, Spriggs, MK

Immunity 1995
11574464 IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding

Hymowitz, SG, Filvaroff, EH, Yin, JP, Lee, J, Cai, L, Risser, P, Maruoka, M, Mao, W, Foster, J, Kelley, RF, Pan, G, Gurney, AL, de Vos, AM, Starovasnik, MA

EMBO J 2001
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
8:IL17RA [plasma membrane] (Homo sapiens)
Active Unit
8 homodimer [extracellular region]
Authored
Jupe, S  (2014-06-04)
Reviewed
Meldal, BH  (2016-01-28)
Messina, F  (2022-02-18)
Created
Jupe, S  (2009-11-20)
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