Reactome | GMPPB converts Mannose-1-phosphate to GDP-Mannose

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GMPPB converts Mannose-1-phosphate to GDP-Mannose Show undefined attributes

authored	[InstanceEdit:749521] Dall'Olio, GM, 2009-11-10
catalystActivity	[CatalystActivity:532540] mannose-1-phosphate guanylyltransferase (GTP) activity of GMPP [cytosol]
catalystActivityReference	[CatalystActivityReference:9909221] mannose-1-phosphate guanylyltransferase activity of GMPP [cytosol] Cryo-EM structures of human GMPPA-GMPPB complex reveal how cells maintain GDP-mannose homeostasis
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:446206] Jassal, B, 2009-11-10
crossReference	[DatabaseIdentifier:12668083] RHEA:15230 [DatabaseIdentifier:9909218] RHEA:15230
dbId	446221
displayName	GMPPB converts Mannose-1-phosphate to GDP-Mannose
edited	[InstanceEdit:446206] Jassal, B, 2009-11-10
eventOf	[Pathway:R-HSA-446205] Synthesis of GDP-mannose - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-532531] Man1P [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9909225] Mutations in GMPPA cause a glycosylation disorder characterized by intellectual disability and autonomic dysfunction [LiteratureReference:749520] Cloning, expression and characterization of the pig liver GDP-mannose pyrophosphorylase. Evidence that GDP-mannose and GDP-Glc pyrophosphorylases are different proteins [LiteratureReference:749506] Purification and properties of guanosine diphosphate hexose pyrophosphorylase from mammalian tissues [LiteratureReference:9909251] Cryo-EM structures of human GMPPA-GMPPB complex reveal how cells maintain GDP-mannose homeostasis
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	GMPPB converts Mannose-1-phosphate to GDP-Mannose alpha-D-mannose 1-phosphate + GTP + H(+) => diphosphate + GDP-alpha-D-mannose
orthologousEvent	[Reaction:R-BTA-446221] GMPPB converts Mannose-1-phosphate to GDP-Mannose - Bos taurus [Reaction:R-SPO-446221] GMPPB converts Mannose-1-phosphate to GDP-Mannose - Schizosaccharomyces pombe [Reaction:R-DDI-446221] GMPPB converts Mannose-1-phosphate to GDP-Mannose - Dictyostelium discoideum [Reaction:R-CEL-446221] GMPPB converts Mannose-1-phosphate to GDP-Mannose - Caenorhabditis elegans [Reaction:R-DME-446221] GMPPB converts Mannose-1-phosphate to GDP-Mannose - Drosophila melanogaster [Reaction:R-GGA-446221] GMPPB converts Mannose-1-phosphate to GDP-Mannose - Gallus gallus [Reaction:R-XTR-446221] GMPPB converts Mannose-1-phosphate to GDP-Mannose - Xenopus tropicalis [Reaction:R-DRE-446221] GMPPB converts Mannose-1-phosphate to GDP-Mannose - Danio rerio [Reaction:R-SSC-446221] GMPPB converts Mannose-1-phosphate to GDP-Mannose - Sus scrofa [Reaction:R-CFA-446221] GMPPB converts Mannose-1-phosphate to GDP-Mannose - Canis familiaris [Reaction:R-RNO-446221] GMPPB converts Mannose-1-phosphate to GDP-Mannose - Rattus norvegicus [Reaction:R-MMU-446221] GMPPB converts Mannose-1-phosphate to GDP-Mannose - Mus musculus
output	[SimpleEntity:R-ALL-162860] GDP-Man [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-HSA-446201] PMM1,2 isomerise Man6P to Man1P - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[NegativeRegulation:9909277] Negative regulation by 'GDP-Man [cytosol]' [PositiveRegulation:9909286] Positive regulation by 'GTP [cytosol]'
regulationReference	[RegulationReference:9909278] Negative regulation by 'GDP-Man [cytosol]' Cryo-EM structures of human GMPPA-GMPPB complex reveal how cells maintain GDP-mannose homeostasis [RegulationReference:9909285] Positive regulation by 'GTP [cytosol]' Cryo-EM structures of human GMPPA-GMPPB complex reveal how cells maintain GDP-mannose homeostasis
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:749519] Gagneux, P, 2010-04-16 [InstanceEdit:9910566] Hill, David P, 2024-05-15
revised	[InstanceEdit:9909260] D'Eustachio, Peter, 2024-05-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-446221
summation	[Summation:749512] Cytosolic mannose 1-phosphate is converted to GDP-Mannose by...
updateTrackers	[UpdateTracker:9910950] Update Tracker - [Reaction:446221] GMPPB converts Mannose-1-phosphate to GDP-Mannose - v89:[addInput, addLiteratureReference, addRegulator, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9910950] Update Tracker - [Reaction:446221] GMPPB converts Mannose-1-phosphate to GDP-Mannose - v89:[addInput, addLiteratureReference, addRegulator, modifyText]
(hasEvent)	[Pathway:R-HSA-446205] Synthesis of GDP-mannose

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