Reactome | GMPPB converts Mannose-1-phosphate to GDP-Mannose

Schema > Reaction > Entries

GMPPB converts Mannose-1-phosphate to GDP-Mannose Show undefined attributes

catalystActivity	[CatalystActivity:10854095] mannose-1-phosphate guanylyltransferase (GTP) activity of GMPP [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10854097
displayName	GMPPB converts Mannose-1-phosphate to GDP-Mannose
eventOf	[Pathway:R-DME-446205] Synthesis of GDP-mannose - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-446221] GMPPB converts Mannose-1-phosphate to GDP-Mannose - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-532531] Man1P [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	GMPPB converts Mannose-1-phosphate to GDP-Mannose alpha-D-mannose 1-phosphate + GTP + H(+) => diphosphate + GDP-alpha-D-mannose
output	[SimpleEntity:R-ALL-162860] GDP-Man [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-DME-446201] PMM1,2 isomerise Man6P to Man1P - Drosophila melanogaster
regulatedBy	[NegativeRegulation:10017894] Negative regulation by 'GDP-Man [cytosol]' [Requirement:R-HSA-72779] Requirement by 'GTP [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-446221
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-446205] Synthesis of GDP-mannose
(inferredTo)	[Reaction:R-HSA-446221] GMPPB converts Mannose-1-phosphate to GDP-Mannose

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