Reactome | Negative regulation by 'GDP-Man [cytosol]'

Schema > NegativeRegulation > Entries

activeUnit	[EntityWithAccessionedSequence:R-HSA-532565] GMPPA [cytosol] - Homo sapiens
activity	[GO_MolecularFunction:11563] mannose-1-phosphate guanylyltransferase (GTP) activity
created	[InstanceEdit:9909279] D'Eustachio, Peter, 2024-05-02
dbId	9909277
displayName	Negative regulation by 'GDP-Man [cytosol]'
modified	[InstanceEdit:9983308] Weiser, Joel, 2026-02-22
regulatedEntity	[Reaction:R-HSA-446221] GMPPB converts Mannose-1-phosphate to GDP-Mannose - Homo sapiens
regulator	[SimpleEntity:R-ALL-162860] GDP-Man [cytosol]
schemaClass	NegativeRegulation

(regulation)	[RegulationReference:9909278] Negative regulation by 'GDP-Man [cytosol]' Cryo-EM structures of human GMPPA-GMPPB complex reveal how cells maintain GDP-mannose homeostasis
(regulatedBy)	[Reaction:R-HSA-446221] GMPPB converts Mannose-1-phosphate to GDP-Mannose

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