Reactome | ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP

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ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP Show undefined attributes

authored	[InstanceEdit:749521] Dall'Olio, GM, 2009-11-10
catalystActivity	[CatalystActivity:449313] N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity of ALG13:ALG14 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:446206] Jassal, B, 2009-11-10
dbId	446207
diseaseReaction	[FailedReaction:R-HSA-5633241] Defective ALG14 does not transfer GlcNAc from UDP-GlcNAc to GlcNAcDOLP - Homo sapiens
displayName	ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP
edited	[InstanceEdit:446206] Jassal, B, 2009-11-10
eventOf	[Pathway:R-HSA-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - Homo sapiens
figure	[Figure:975569] /figures/2_GlcNAc2PPDol.png
followingEvent	[Reaction:R-HSA-446218] Addition of the first mannose to the N-glycan precursor by ALG1 - Homo sapiens
input	[SimpleEntity:R-ALL-449222] GlcNAcDOLDP [cytoplasmic side of endoplasmic reticulum membrane] [SimpleEntity:R-ALL-162756] UDP-GlcNAc [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:449340] Alg14 recruits Alg13 to the cytoplasmic face of the endoplasmic reticulum to form a novel bipartite UDP-N-acetylglucosamine transferase required for the second step of N-linked glycosylation
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP Addition of the second N-acetyl-glucosamine to the N-glycan precursor
orthologousEvent	[Reaction:R-PFA-446207] ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP - Plasmodium falciparum [Reaction:R-SPO-446207] ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP - Schizosaccharomyces pombe [Reaction:R-CEL-446207] ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP - Caenorhabditis elegans [Reaction:R-DME-446207] ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP - Drosophila melanogaster [Reaction:R-GGA-446207] ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP - Gallus gallus [Reaction:R-XTR-446207] ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP - Xenopus tropicalis [Reaction:R-DRE-446207] ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP - Danio rerio [Reaction:R-SSC-446207] ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP - Sus scrofa [Reaction:R-BTA-446207] ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP - Bos taurus [Reaction:R-CFA-446207] ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP - Canis familiaris [Reaction:R-RNO-446207] ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP - Rattus norvegicus [Reaction:R-MMU-446207] ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP - Mus musculus
output	[SimpleEntity:R-ALL-449293] N,N'-DCDOLDP [cytoplasmic side of endoplasmic reticulum membrane] [SimpleEntity:R-ALL-110096] UDP [cytosol]
precedingEvent	[Reaction:R-HSA-446191] Addition of N-acetyl-D-glucosamine to Dolichyl phosphate - Homo sapiens
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:749519] Gagneux, P, 2010-04-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-446207
summation	[Summation:446220] A second N-acetylglucosamine is added to the N-glycan precur...
systematicName	ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP
updateTrackers	[UpdateTracker:9790206] Update Tracker - [Reaction:446207] ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP - v34:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9790206] Update Tracker - [Reaction:446207] ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP - v34:[modifyText]
(normalReaction)	[FailedReaction:R-HSA-5633241] Defective ALG14 does not transfer GlcNAc from UDP-GlcNAc to GlcNAcDOLP
(hasEvent)	[Pathway:R-HSA-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
(precedingEvent)	[Reaction:R-HSA-446218] Addition of the first mannose to the N-glycan precursor by ALG1