Reactome | Addition of N-acetyl-D-glucosamine to Dolichyl phosphate

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Addition of N-acetyl-D-glucosamine to Dolichyl phosphate Show undefined attributes

authored	[InstanceEdit:749521] Dall'Olio, GM, 2009-11-10
catalystActivity	[CatalystActivity:449231] UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity of DPAGT1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:446206] Jassal, B, 2009-11-10
dbId	446191
diseaseReaction	[FailedReaction:R-HSA-4549334] Defective DPAGT1 does not transfer GlcNAc to DOLP - Homo sapiens
displayName	Addition of N-acetyl-D-glucosamine to Dolichyl phosphate
edited	[InstanceEdit:446206] Jassal, B, 2009-11-10
eventOf	[Pathway:R-HSA-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - Homo sapiens
figure	[Figure:975555] /figures/1_GlcNAc1PPDol.png
followingEvent	[Reaction:R-HSA-446207] ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP - Homo sapiens
input	[SimpleEntity:R-ALL-449299] DOLP [cytoplasmic side of endoplasmic reticulum membrane] [SimpleEntity:R-ALL-162756] UDP-GlcNAc [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:449302] Deficiency of UDP-GlcNAc:Dolichol Phosphate N-Acetylglucosamine-1 Phosphate Transferase (DPAGT1) causes a novel congenital disorder of Glycosylation Type Ij [LiteratureReference:449238] Cloning and functional expression of the human GlcNAc-1-P transferase, the enzyme for the committed step of the dolichol cycle, by heterologous complementation in Saccharomyces cerevisiae [LiteratureReference:4549335] Mutations in DPAGT1 cause a limb-girdle congenital myasthenic syndrome with tubular aggregates
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Addition of N-acetyl-D-glucosamine to Dolichyl phosphate
orthologousEvent	[Reaction:R-PFA-446191] Addition of N-acetyl-D-glucosamine to Dolichyl phosphate - Plasmodium falciparum [Reaction:R-SCE-446191] Addition of N-acetyl-D-glucosamine to Dolichyl phosphate - Saccharomyces cerevisiae [Reaction:R-SPO-446191] Addition of N-acetyl-D-glucosamine to Dolichyl phosphate - Schizosaccharomyces pombe [Reaction:R-DDI-446191] Addition of N-acetyl-D-glucosamine to Dolichyl phosphate - Dictyostelium discoideum [Reaction:R-CEL-446191] Addition of N-acetyl-D-glucosamine to Dolichyl phosphate - Caenorhabditis elegans [Reaction:R-DME-446191] Addition of N-acetyl-D-glucosamine to Dolichyl phosphate - Drosophila melanogaster [Reaction:R-GGA-446191] Addition of N-acetyl-D-glucosamine to Dolichyl phosphate - Gallus gallus [Reaction:R-XTR-446191] Addition of N-acetyl-D-glucosamine to Dolichyl phosphate - Xenopus tropicalis [Reaction:R-DRE-446191] Addition of N-acetyl-D-glucosamine to Dolichyl phosphate - Danio rerio [Reaction:R-SSC-446191] Addition of N-acetyl-D-glucosamine to Dolichyl phosphate - Sus scrofa [Reaction:R-BTA-446191] Addition of N-acetyl-D-glucosamine to Dolichyl phosphate - Bos taurus [Reaction:R-CFA-446191] Addition of N-acetyl-D-glucosamine to Dolichyl phosphate - Canis familiaris [Reaction:R-RNO-446191] Addition of N-acetyl-D-glucosamine to Dolichyl phosphate - Rattus norvegicus [Reaction:R-MMU-446191] Addition of N-acetyl-D-glucosamine to Dolichyl phosphate - Mus musculus
output	[SimpleEntity:R-ALL-449222] GlcNAcDOLDP [cytoplasmic side of endoplasmic reticulum membrane] [SimpleEntity:R-ALL-109402] UMP [cytosol]
precedingEvent	[Reaction:R-HSA-446200] DOLPP1 dephosphorylates DOLDP to DOLP - Homo sapiens [Reaction:R-HSA-446204] GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine - Homo sapiens [Reaction:R-HSA-446195] DOLK phosphorylates DCHOL to DOLP - Homo sapiens
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:749519] Gagneux, P, 2010-04-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-446191
summation	[Summation:446217] In the first step of N glycan precursor (LLO) synthesis, N a...
updateTrackers	[UpdateTracker:9785765] Update Tracker - [Reaction:446191] Addition of N-acetyl-D-glucosamine to Dolichyl phosphate - v51:[addLiteratureReference, modifyText] [UpdateTracker:9786878] Update Tracker - [Reaction:446191] Addition of N-acetyl-D-glucosamine to Dolichyl phosphate - v47:[modifyText] [UpdateTracker:9790325] Update Tracker - [Reaction:446191] Addition of N-acetyl-D-glucosamine to Dolichyl phosphate - v34:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9785765] Update Tracker - [Reaction:446191] Addition of N-acetyl-D-glucosamine to Dolichyl phosphate - v51:[addLiteratureReference, modifyText] [UpdateTracker:9786878] Update Tracker - [Reaction:446191] Addition of N-acetyl-D-glucosamine to Dolichyl phosphate - v47:[modifyText] [UpdateTracker:9790325] Update Tracker - [Reaction:446191] Addition of N-acetyl-D-glucosamine to Dolichyl phosphate - v34:[modifyText]
(normalReaction)	[FailedReaction:R-HSA-4549334] Defective DPAGT1 does not transfer GlcNAc to DOLP
(hasEvent)	[Pathway:R-HSA-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
(precedingEvent)	[Reaction:R-HSA-446207] ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP

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