ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP

Stable Identifier
R-HSA-446207
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Addition of the second N-acetyl-glucosamine to the N-glycan precursor
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ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP
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A second N-acetylglucosamine is added to the N-glycan precursor via a beta-1,4 linkage. This reaction is catalyzed by the ALG13:ALG14 complex, in which ALG13 functions as the catalyst and ALG14 functions as a membrane anchor which recruits ALG13 to the cytosolic face of ER (Gao XD et al, 2005).

Literature References
Participants
Input
Output
Participant Of
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Catalyst Activity
Catalyst Activity
Title
N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity of ALG13:ALG14 [endoplasmic reticulum membrane]
Physical Entity
ALG13:ALG14 [endoplasmic reticulum membrane]
Activity
N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity (0004577)
Orthologous Events
ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Bos taurus)
ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Caenorhabditis elegans)
ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Canis familiaris)
ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Danio rerio)
ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Drosophila melanogaster)
ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Gallus gallus)
ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Mus musculus)
ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Plasmodium falciparum)
ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Rattus norvegicus)
ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Schizosaccharomyces pombe)
ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Sus scrofa)
Authored
Dall'Olio, GM  (2009-11-10)
Reviewed
Gagneux, P  (2010-04-16)
Created
Jassal, B  (2009-11-10)