Reactome | ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP

ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP

Stable Identifier

R-HSA-446207

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Addition of the second N-acetyl-glucosamine to the N-glycan precursor

ReviewStatus

5/5

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General

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ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP

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A second N-acetylglucosamine is added to the N-glycan precursor via a beta-1,4 linkage. This reaction is catalyzed by the ALG13:ALG14 complex, in which ALG13 functions as the catalyst and ALG14 functions as a membrane anchor which recruits ALG13 to the cytosolic face of ER (Gao XD et al, 2005).

Literature References

PubMed ID	Title	Journal	Year
16100110	Alg14 recruits Alg13 to the cytoplasmic face of the endoplasmic reticulum to form a novel bipartite UDP-N-acetylglucosamine transferase required for the second step of N-linked glycosylation Gao, XD, Tachikawa, H, Sato, T, Jigami, Y, Dean, N	J Biol Chem	2005

Participants

Input

Output

Participates

as an event of

Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)

Catalyst Activity

N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity of ALG13:ALG14 [endoplasmic reticulum membrane]

Physical Entity

ALG13:ALG14 [endoplasmic reticulum membrane] (Homo sapiens)

Activity

N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity (GO:0004577)

Orthologous Events

ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Bos taurus)

ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Caenorhabditis elegans)

ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Canis familiaris)

ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Drosophila melanogaster)

ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Gallus gallus)

ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Mus musculus)

ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Plasmodium falciparum)

ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Rattus norvegicus)

ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Schizosaccharomyces pombe)

ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Sus scrofa)

ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Xenopus tropicalis)

Authored

Dall'Olio, GM (2009-11-10)

Reviewed

Gagneux, P (2010-04-16)

Created

Jassal, B (2009-11-10)

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