Reactome | GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors

GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors

Stable Identifier

R-HSA-444731

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors

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The subfamily of G protein-coupled receptors comprising GPR4, OGR1, TDAG8, and G2A was originally characterized as a group of proteins mediating biological responses to the lipid messengers sphingosylphosphorylcholine (SPC), lysophosphatidylcholine (LPC), and psychosine. This was later replaced by reports that OGR1 and GPR4 sense acidic pH. GPR4, OGR1, and TDAG8 are now considered as proton-sensing receptors.

Literature References

PubMed ID	Title	Journal	Year
15326175	TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptor Wang, JQ, Kon, J, Mogi, C, Tobo, M, Damirin, A, Sato, K, Komachi, M, Malchinkhuu, E, Murata, N, Kimura, T, Kuwabara, A, Wakamatsu, K, Koizumi, H, Uede, T, Tsujimoto, G, Kurose, H, Sato, T, Harada, A, Misawa, N, Tomura, H, Okajima, F	J Biol Chem	2004
17462861	Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms Tobo, M, Tomura, H, Mogi, C, Wang, JQ, Liu, JP, Komachi, M, Damirin, A, Kimura, T, Murata, N, Kurose, H, Sato, K, Okajima, F	Cell Signal	2007
15280385	G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine Murakami, N, Yokomizo, T, Okuno, T, Shimizu, T	J Biol Chem	2004
12955148	Proton-sensing G-protein-coupled receptors Ludwig, MG, Vanek, M, Guerini, D, Gasser, JA, Jones, CE, Junker, U, Hofstetter, H, Wolf, RM, Seuwen, K	Nature	2003