GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors

Stable Identifier
R-HSA-444731
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The subfamily of G protein-coupled receptors comprising GPR4, OGR1, TDAG8, and G2A was originally characterized as a group of proteins mediating biological responses to the lipid messengers sphingosylphosphorylcholine (SPC), lysophosphatidylcholine (LPC), and psychosine. This was later replaced by reports that OGR1 and GPR4 sense acidic pH. GPR4, OGR1, and TDAG8 are now considered as proton-sensing receptors.

Literature References
PubMed ID Title Journal Year
17462861 Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms

Tobo, M, Tomura, H, Mogi, C, Wang, JQ, Liu, JP, Komachi, M, Damirin, A, Kimura, T, Murata, N, Kurose, H, Sato, K, Okajima, F

Cell Signal 2007
15326175 TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptor

Wang, JQ, Kon, J, Mogi, C, Tobo, M, Damirin, A, Sato, K, Komachi, M, Malchinkhuu, E, Murata, N, Kimura, T, Kuwabara, A, Wakamatsu, K, Koizumi, H, Uede, T, Tsujimoto, G, Kurose, H, Sato, T, Harada, A, Misawa, N, Tomura, H, Okajima, F

J Biol Chem 2004
15280385 G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine

Murakami, N, Yokomizo, T, Okuno, T, Shimizu, T

J Biol Chem 2004
12955148 Proton-sensing G-protein-coupled receptors

Ludwig, MG, Vanek, M, Guerini, D, Gasser, JA, Jones, CE, Junker, U, Hofstetter, H, Wolf, RM, Seuwen, K

Nature 2003
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created