GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors

Stable Identifier
R-HSA-444731
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Reaction
Species
Homo sapiens
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The subfamily of G protein-coupled receptors comprising GPR4, OGR1, TDAG8, and G2A was originally characterized as a group of proteins mediating biological responses to the lipid messengers sphingosylphosphorylcholine (SPC), lysophosphatidylcholine (LPC), and psychosine. This was later replaced by reports that OGR1 and GPR4 sense acidic pH. GPR4, OGR1, and TDAG8 are now considered as proton-sensing receptors.

Literature References
PubMed ID Title Journal Year
15326175 TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptor

Wakamatsu, K, Murata, N, Misawa, N, Kuwabara, A, Tomura, H, Sato, K, Harada, A, Damirin, A, Wang, JQ, Tobo, M, Mogi, C, Kimura, T, Sato, T, Kon, J, Kurose, H, Koizumi, H, Malchinkhuu, E, Okajima, F, Tsujimoto, G, Komachi, M, Uede, T

J Biol Chem 2004
17462861 Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms

Wang, JQ, Liu, JP, Tobo, M, Mogi, C, Murata, N, Kimura, T, Sato, K, Tomura, H, Kurose, H, Okajima, F, Komachi, M, Damirin, A

Cell Signal 2007
15280385 G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine

Murakami, N, Yokomizo, T, Okuno, T, Shimizu, T

J Biol Chem 2004
12955148 Proton-sensing G-protein-coupled receptors

Hofstetter, H, Guerini, D, Ludwig, MG, Wolf, RM, Junker, U, Jones, CE, Vanek, M, Seuwen, K, Gasser, JA

Nature 2003
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