Reactome | Activated calmodulin binds ADCY1,ADCY8

Schema > Reaction > Entries

authored	[InstanceEdit:9624342] Orlic-Milacic, Marija, 2018-10-10
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9617534] Orlic-Milacic, Marija, 2018-08-28
dbId	9617535
displayName	Activated calmodulin binds ADCY1,ADCY8
edited	[InstanceEdit:9628239] Orlic-Milacic, Marija, 2018-11-07
eventOf	[Pathway:R-HSA-442720] CREB1 phosphorylation through the activation of Adenylate Cyclase - Homo sapiens
followingEvent	[Reaction:R-HSA-442715] Calmodulin-activated adenylate cyclases ADCY1 and ADCY8 generate cAMP - Homo sapiens
inferredFrom	[Reaction:R-NUL-9617570] Activated calmodulin binds ADCY1 - Bos taurus [Reaction:R-RNO-9617562] Activated calmodulin binds Adcy8 - Rattus norvegicus
input	[DefinedSet:R-HSA-443461] ADCY1,ADCY8 [plasma membrane] [Complex:R-HSA-74294] CALM1:4xCa2+ [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated calmodulin binds ADCY1,ADCY8
output	[Complex:R-HSA-9617533] ADCY1,ADCY8:CALM1:4xCa2+ [plasma membrane]
precedingEvent	[Reaction:R-HSA-74448] Calcium binds calmodulin - Homo sapiens
releaseDate	2018-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9627687] Yi, Feng, 2018-11-02 [InstanceEdit:9628437] Hansen, Kasper B, 2018-11-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9617535
summation	[Summation:9617558] Calmodulin (CALM1, also known as CaM), activated by binding ...

(hasEvent)	[Pathway:R-HSA-442720] CREB1 phosphorylation through the activation of Adenylate Cyclase
(precedingEvent)	[Reaction:R-HSA-442715] Calmodulin-activated adenylate cyclases ADCY1 and ADCY8 generate cAMP
(inferredTo)	[Reaction:R-RNO-9617562] Activated calmodulin binds Adcy8 [Reaction:R-NUL-9617570] Activated calmodulin binds ADCY1

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