Reactome | VEGFR2 autophosphorylates

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VEGFR2 autophosphorylates Show undefined attributes

authored	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
catalystActivity	[CatalystActivity:4420144] protein tyrosine kinase activity of VEGFA-165 dimer:VEGFR2 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643911] protein tyrosine kinase activity of VEGFA-165 dimer:VEGFR2 dimer [plasma membrane] Biological activity and phosphorylation sites of the bacterially expressed cytosolic domain of the KDR VEGF-receptor
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
dbId	4420117
displayName	VEGFR2 autophosphorylates
edited	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
eventOf	[Pathway:R-HSA-4420097] VEGFA-VEGFR2 Pathway - Homo sapiens
followingEvent	[Reaction:R-HSA-4420107] p-6Y-VEGFR2 binds SHC-transforming protein 2 - Homo sapiens [Reaction:R-HSA-5218815] p-6Y-VEGFR2 binds NCK - Homo sapiens [Reaction:R-HSA-5218818] Integrin alphaVbeta3 binds p-6Y-VEGFR2 - Homo sapiens [Reaction:R-HSA-4420099] p-6Y-VEGFR2 binds SHB - Homo sapiens [Reaction:R-HSA-5218852] p-6Y-VEGFR2 binds PI3K - Homo sapiens [Reaction:R-HSA-4420143] p-6Y-VEGFR2 binds SH2D2A - Homo sapiens [Reaction:R-HSA-4420153] p-6Y-VEGFR2 binds PLCG1 - Homo sapiens
input	12 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-195402] VEGFA-165 dimer:VEGFR2 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-195382] VEGFR2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4420214] Interactions of FLT-1 and KDR with phospholipase C gamma: identification of the phosphotyrosine binding sites [LiteratureReference:4420132] VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis [LiteratureReference:4420136] Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	VEGFR2 autophosphorylates
orthologousEvent	[Reaction:R-GGA-4420117] VEGFR2 autophosphorylates - Gallus gallus [Reaction:R-XTR-4420117] VEGFR2 autophosphorylates - Xenopus tropicalis [Reaction:R-DRE-4420117] VEGFR2 autophosphorylates - Danio rerio [Reaction:R-SSC-4420117] VEGFR2 autophosphorylates - Sus scrofa [Reaction:R-BTA-4420117] VEGFR2 autophosphorylates - Bos taurus [Reaction:R-CFA-4420117] VEGFR2 autophosphorylates - Canis familiaris [Reaction:R-RNO-4420117] VEGFR2 autophosphorylates - Rattus norvegicus [Reaction:R-MMU-4420117] VEGFR2 autophosphorylates - Mus musculus
output	12 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-4420101] VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane]
precedingEvent	[Reaction:R-HSA-194310] VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization - Homo sapiens [Reaction:R-HSA-9691215] VEGFA-165 dimer binds VEGFR2 dimer - Homo sapiens
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5432673] Welsh, Michael, Berger, Philipp, Ballmer-Hofer, Kurt, 2014-05-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4420117
summation	[Summation:4420183] Binding of VEGFA to VEGFR2 induces receptor dimerization and...
updateTrackers	[UpdateTracker:9776795] Update Tracker - [Reaction:4420117] VEGFR2 autophosphorylates - v74:[addInput]

Referrals

(updatedInstance)	[UpdateTracker:9776795] Update Tracker - [Reaction:4420117] VEGFR2 autophosphorylates - v74:[addInput]
(hasEvent)	[Pathway:R-HSA-4420097] VEGFA-VEGFR2 Pathway
(precedingEvent)	[Reaction:R-HSA-4420107] p-6Y-VEGFR2 binds SHC-transforming protein 2 [Reaction:R-HSA-5218815] p-6Y-VEGFR2 binds NCK [Reaction:R-HSA-5218818] Integrin alphaVbeta3 binds p-6Y-VEGFR2 [Reaction:R-HSA-4420099] p-6Y-VEGFR2 binds SHB [Reaction:R-HSA-5218852] p-6Y-VEGFR2 binds PI3K [Reaction:R-HSA-4420143] p-6Y-VEGFR2 binds SH2D2A [Reaction:R-HSA-4420153] p-6Y-VEGFR2 binds PLCG1

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