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p-6Y-VEGFR2 binds PLCG1
Stable Identifier
R-HSA-4420153
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFR2 mediated cell proliferation (Homo sapiens)
p-6Y-VEGFR2 binds PLCG1 (Homo sapiens)
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Phospholipase C-gamma 1 (PLCG1) plays a pivotal role in angiogenesis and VEGFR2 signal transduction. VEGFR2-mediated activation of PLCG1 in certain endothelial cellular backgrounds is suggested to stimulate cell proliferation and in other endothelial cells to stimulate differentiation and tubulogenesis (Rahimi 2006). Phosphorylated tyrosine 1175 of VEGFR2 provides the binding site for PLCG1, SHC-transforming protein 2 (SHC2/SCK) and SH2 domain-containing adapter protein B (SHB) (Takahashi et al. 2001). Binding of PLCG1 activates protein kinase C (PKC) and this in-turn stimulates mitogen-activated protein (MAP) kinase (MAPK)-dependent pathway and cell proliferation (McLaughlin & Vries 2001).
Literature References
PubMed ID
Title
Journal
Year
11387210
A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells
Chida, K
,
Shibuya, M
,
Takahashi, T
,
Yamaguchi, S
EMBO J
2001
11600407
Role of PLCgamma and Ca(2+) in VEGF- and FGF-induced choroidal endothelial cell proliferation
McLaughlin, AP
,
De Vries, GW
Am. J. Physiol., Cell Physiol.
2001
Participants
Input
PLCG1 [cytosol]
(Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane]
(Homo sapiens)
Output
VEGFA dimer:p-6Y-VEGFR2 dimer:PLCG1 [plasma membrane]
(Homo sapiens)
Participates
as an event of
VEGFR2 mediated cell proliferation (Homo sapiens)
Orthologous Events
p-6Y-VEGFR2 binds PLCG1 (Bos taurus)
p-6Y-VEGFR2 binds PLCG1 (Canis familiaris)
p-6Y-VEGFR2 binds PLCG1 (Danio rerio)
p-6Y-VEGFR2 binds PLCG1 (Gallus gallus)
p-6Y-VEGFR2 binds PLCG1 (Mus musculus)
p-6Y-VEGFR2 binds PLCG1 (Rattus norvegicus)
p-6Y-VEGFR2 binds PLCG1 (Sus scrofa)
p-6Y-VEGFR2 binds PLCG1 (Xenopus tropicalis)
Authored
Garapati, P V (2013-08-30)
Reviewed
Ballmer-Hofer, K (2014-05-12)
Welsh, M (2014-05-12)
Berger, P (2014-05-12)
Created
Garapati, P V (2013-08-30)
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