p-6Y-VEGFR2 binds PLCG1

Stable Identifier
R-HSA-4420153
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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p-6Y-VEGFR2 binds PLCG1
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Phospholipase C-gamma 1 (PLCG1) plays a pivotal role in angiogenesis and VEGFR2 signal transduction. VEGFR2-mediated activation of PLCG1 in certain endothelial cellular backgrounds is suggested to stimulate cell proliferation and in other endothelial cells to stimulate differentiation and tubulogenesis (Rahimi 2006). Phosphorylated tyrosine 1175 of VEGFR2 provides the binding site for PLCG1, SHC-transforming protein 2 (SHC2/SCK) and SH2 domain-containing adapter protein B (SHB) (Takahashi et al. 2001). Binding of PLCG1 activates protein kinase C (PKC) and this in-turn stimulates mitogen-activated protein (MAP) kinase (MAPK)-dependent pathway and cell proliferation (McLaughlin & Vries 2001).

Literature References
PubMed ID Title Journal Year
11600407 Role of PLCgamma and Ca(2+) in VEGF- and FGF-induced choroidal endothelial cell proliferation

McLaughlin, AP, De Vries, GW

Am. J. Physiol., Cell Physiol. 2001
11387210 A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells

Takahashi, T, Yamaguchi, S, Chida, K, Shibuya, M

EMBO J 2001
Participants
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Orthologous Events
p-6Y-VEGFR2 binds PLCG1 (Bos taurus)
p-6Y-VEGFR2 binds PLCG1 (Canis familiaris)
p-6Y-VEGFR2 binds PLCG1 (Danio rerio)
p-6Y-VEGFR2 binds PLCG1 (Mus musculus)
p-6Y-VEGFR2 binds PLCG1 (Rattus norvegicus)
p-6Y-VEGFR2 binds PLCG1 (Sus scrofa)
p-6Y-VEGFR2 binds PLCG1 (Xenopus tropicalis)
Authored
Garapati, P V  (2013-08-30)
Reviewed
Welsh, M  (2014-05-12)
Berger, P  (2014-05-12)
Ballmer-Hofer, K  (2014-05-12)
Created
Garapati, P V  (2013-08-30)