Reactome | VEGFR2 autophosphorylates

Schema > Reaction > Entries

VEGFR2 autophosphorylates Show undefined attributes

catalystActivity	[CatalystActivity:10608987] protein tyrosine kinase activity of VEGFA-165 dimer:VEGFR2 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10608989
displayName	VEGFR2 autophosphorylates
eventOf	[Pathway:R-DRE-4420097] VEGFA-VEGFR2 Pathway - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-5218815] p-6Y-VEGFR2 binds NCK - Danio rerio [Reaction:R-DRE-5218818] Integrin alphaVbeta3 binds p-6Y-VEGFR2 - Danio rerio [Reaction:R-DRE-4420143] p-6Y-VEGFR2 binds SH2D2A - Danio rerio [Reaction:R-DRE-4420153] p-6Y-VEGFR2 binds PLCG1 - Danio rerio
inferredFrom	[Reaction:R-HSA-4420117] VEGFR2 autophosphorylates - Homo sapiens
input	12 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-DRE-195382-3] Homologues of VEGFR2 [plasma membrane] [Complex:R-DRE-195402] VEGFA-165 dimer:VEGFR2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	VEGFR2 autophosphorylates
output	12 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-DRE-4420101] VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane]
precedingEvent	[Reaction:R-DRE-194310] VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization - Danio rerio [Reaction:R-DRE-9691215] VEGFA-165 dimer binds VEGFR2 dimer - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-4420117
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-4420097] VEGFA-VEGFR2 Pathway
(precedingEvent)	[Reaction:R-DRE-5218815] p-6Y-VEGFR2 binds NCK [Reaction:R-DRE-5218818] Integrin alphaVbeta3 binds p-6Y-VEGFR2 [Reaction:R-DRE-4420143] p-6Y-VEGFR2 binds SH2D2A [Reaction:R-DRE-4420153] p-6Y-VEGFR2 binds PLCG1
(inferredTo)	[Reaction:R-HSA-4420117] VEGFR2 autophosphorylates