Reactome | VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization

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VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization Show undefined attributes

authored	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:194309] Gopinathrao, G, 2007-03-12 19:24:15
dbId	194310
displayName	VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization
edited	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
eventOf	[Pathway:R-HSA-195399] VEGF binds to VEGFR leading to receptor dimerization - Homo sapiens
figure	[Figure:195456] /figures/vegfr2.jpg
followingEvent	[Reaction:R-HSA-4420117] VEGFR2 autophosphorylates - Homo sapiens
input	[DefinedSet:R-HSA-195393] VEGFA,C,D dimers [extracellular region] 2 × [EntityWithAccessionedSequence:R-HSA-195382] VEGFR2 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:195487] A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF [LiteratureReference:195485] Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site [LiteratureReference:195459] Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites [LiteratureReference:195510] A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases [LiteratureReference:195496] Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4) [LiteratureReference:195471] Identification of a novel platelet-derived growth factor-like gene, fallotein, in the human reproductive tract [LiteratureReference:195455] Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor [LiteratureReference:195484] A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization
orthologousEvent	[Reaction:R-GGA-194310] VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization - Gallus gallus [Reaction:R-XTR-194310] VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization - Xenopus tropicalis [Reaction:R-DRE-194310] VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization - Danio rerio [Reaction:R-SSC-194310] VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization - Sus scrofa [Reaction:R-BTA-194310] VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization - Bos taurus [Reaction:R-CFA-194310] VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization - Canis familiaris [Reaction:R-RNO-194310] VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization - Rattus norvegicus [Reaction:R-MMU-194310] VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization - Mus musculus
output	[Complex:R-HSA-215139] VEGFR2:VEGFA,C,D [plasma membrane]
precedingEvent	[Reaction:R-HSA-195378] Homodimerization of VEGF proteins - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:215257] Claesson-Welsh, L, 2008-02-28 00:15:17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-194310
summation	[Summation:195572] VEGFR-2 binds VEGF-A, -C, -D, and -E homodimers. VEGFR-2 is ...

Referrals

(hasEvent)	[Pathway:R-HSA-195399] VEGF binds to VEGFR leading to receptor dimerization
(precedingEvent)	[Reaction:R-HSA-4420117] VEGFR2 autophosphorylates

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