Reactome | TCF/LEF:CTNNB1 promote transcription of AXIN2

Schema > BlackBoxEvent > Entries

TCF/LEF:CTNNB1 promote transcription of AXIN2 Show undefined attributes

authored	[InstanceEdit:4415000] Rothfels, K, 2013-08-23
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:4411356] Rothfels, K, 2013-08-23
dbId	4411372
displayName	TCF/LEF:CTNNB1 promote transcription of AXIN2
edited	[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
eventOf	[Pathway:R-HSA-4411364] Binding of TCF/LEF:CTNNB1 to target gene promoters - Homo sapiens
followingEvent	[Reaction:R-HSA-4641134] SMURF2 binds AXIN - Homo sapiens [Reaction:R-HSA-3640862] Tankyrase binds AXIN - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-4411327] AXIN2 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4411393] Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling [LiteratureReference:4411400] Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors [LiteratureReference:4411386] Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway [LiteratureReference:3322327] Telomerase modulates Wnt signalling by association with target gene chromatin [LiteratureReference:4416733] Differential control of Wnt target genes involves epigenetic mechanisms and selective promoter occupancy by T-cell factors
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TCF/LEF:CTNNB1 promote transcription of AXIN2
output	[EntityWithAccessionedSequence:R-HSA-3640821] AXIN2 [cytosol]
precedingEvent	[Reaction:R-HSA-4411351] TCF/LEF:CTNNB1 bind the AXIN2 gene - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-4411395] Positive gene expression regulation by 'TCF/LEF:CTNNB1:AXIN2 gene [nucleoplasm]'
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-4411372
summation	[Summation:4411363] Each of the four TCF/LEF transcription factors have been sho...

Referrals

(hasEvent)	[Pathway:R-HSA-4411364] Binding of TCF/LEF:CTNNB1 to target gene promoters
(precedingEvent)	[Reaction:R-HSA-4641134] SMURF2 binds AXIN [Reaction:R-HSA-3640862] Tankyrase binds AXIN