TP53 binds promoters of MIR34 genes

Stable Identifier
R-HSA-4395236
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

TP53 (p53) binds to the conserved p53 binding site located in the vicinity of the MIR34A transcription start (Chang et al. 2007, Raver-Shapira et al. 2007). TP53 also binds to conserved p53 binding sites in the promoter of clustered MIR34B and MIR34C genes, and the transcription of MIR34B and MIR34C microRNAs is directly positively regulated by p53 (He et al. 2007, Corney et al. 2007).

Literature References
PubMed ID Title Journal Year
17823410 MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth

Corney, DC, Flesken-Nikitin, A, Godwin, AK, Wang, W, Nikitin, AY

Cancer Res 2007
17540598 Transcriptional activation of miR-34a contributes to p53-mediated apoptosis

Raver-Shapira, N, Marciano, E, Meiri, E, Spector, Y, Rosenfeld, N, Moskovits, N, Bentwich, Z, Oren, M

Mol Cell 2007
17554337 A microRNA component of the p53 tumour suppressor network

He, L, He, X, Lim, LP, de Stanchina, E, Xuan, Z, Liang, Y, Xue, W, Zender, L, Magnus, J, Ridzon, D, Jackson, AL, Linsley, PS, Chen, C, Lowe, SW, Cleary, MA, Hannon, GJ

Nature 2007
17540599 Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis

Chang, TC, Wentzel, EA, Kent, OA, Ramachandran, K, Mullendore, M, Lee, KH, Feldmann, G, Yamakuchi, M, Ferlito, M, Lowenstein, CJ, Arking, DE, Beer, MA, Maitra, A, Mendell, JT

Mol Cell 2007
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