Reactome | ZnT5 transports zinc into secretory granules in pancreatic beta cells

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ZnT5 transports zinc into secretory granules in pancreatic beta cells Show undefined attributes

catalystActivity	[CatalystActivity:10016993] zinc ion transmembrane transporter activity of SLC30A5 [secretory granule membrane]
category	transition
compartment	[Compartment:1462052] secretory granule lumen [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10016995
displayName	ZnT5 transports zinc into secretory granules in pancreatic beta cells
eventOf	[Pathway:R-MMU-435368] Zinc efflux and compartmentalization by the SLC30 family - Mus musculus [Pathway:R-MMU-264876] Insulin processing - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-437085] ZnT5 transports zinc into secretory granules in pancreatic beta cells - Homo sapiens
input	[SimpleEntity:R-ALL-29426] Zn2+ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ZnT5 transports zinc into secretory granules in pancreatic beta cells
output	[SimpleEntity:R-ALL-216785] Zn2+ [secretory granule lumen]
precedingEvent	[Reaction:R-MMU-442422] SLC39A1-4 transports Zn2+ from extracellular region to cytosol - Mus musculus [Reaction:R-MMU-442317] ZIP6 and ZIP14 mediate zinc influx into cells - Mus musculus [Reaction:R-MMU-442393] ZIP7 mediates zinc efflux from the endoplasmic reticulum - Mus musculus [Reaction:R-MMU-442387] ZIP8 mediates zinc influx into cells - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-437085
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-264876] Insulin processing [Pathway:R-MMU-435368] Zinc efflux and compartmentalization by the SLC30 family
(inferredTo)	[Reaction:R-HSA-437085] ZnT5 transports zinc into secretory granules in pancreatic beta cells

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