Reactome | ZnT5 transports zinc into secretory granules in pancreatic beta cells

ZnT5 transports zinc into secretory granules in pancreatic beta cells

Stable Identifier

R-HSA-437085

Type

Reaction [transition]

Species

Homo sapiens

Compartment

secretory granule lumen, cytosol

ReviewStatus

5/5

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Transport of small molecules (Homo sapiens)

- SLC-mediated transmembrane transport (Homo sapiens)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
    - Metal ion SLC transporters (Homo sapiens)
      - Zinc transporters (Homo sapiens)
        
        Zinc efflux and compartmentalization by the SLC30 family (Homo sapiens)
        
        ZnT5 transports zinc into secretory granules in pancreatic beta cells (Homo sapiens)

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ZnT5 transports zinc into secretory granules in pancreatic beta cells

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The human gene SLC30A5 encodes the zinc transporter ZnT5. This protein is widely expressed but is most abundant in pancreatic beta cells (Kambe T et al, 2002). In these cells, ZnT5 mediates the transport of zinc into secretory granules that contain insulin.

Literature References

PubMed ID	Title	Journal	Year
11904301	Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells Nagao, M, Mori, K, Sasaki, R, Yamaguchi-Iwai, Y, Kambe, T, Amano, T, Hirose, J, Sugiura, N, Iwanaga, T, Narita, H	J Biol Chem	2002