MATEs mediate extrusion of xenobiotics

Stable Identifier
R-HSA-434650
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The human gene family SLC47 encodes 2 multidrug and toxin extrusion (MATE) proteins. Mammalian MATE-type transporters are responsible for the final step in the excretion of metabolic waste and xenobiotic organic cations in the kidney and liver through electroneutral exchange of H(+).
MATE1 is primarily expressed in the kidney and liver, where it is localized to the luminal membranes of the urinary tubules and bile canaliculi. When expressed in HEK293 cells, MATE1 mediates H(+)-coupled electroneutral exchange of various drugs (Otsuka M et al, 2005). MATE2 is a human kidney-specific H+/organic cation antiporter that is responsible for the tubular secretion of cationic drugs across the brush border membranes (Masuda S et al, 2006). Substrates for both MATEs include tetraethylammonium, 1-methyl-4-phenylpyridinium, cimetidine, metformin, creatinine, guanidine and procainamide (Tanihara Y et al, 2007).

Literature References
PubMed ID Title Journal Year
16330770 A human transporter protein that mediates the final excretion step for toxic organic cations

Otsuka, M, Matsumoto, T, Morimoto, R, Arioka, S, Omote, H, Moriyama, Y

Proc Natl Acad Sci U S A 2005
16807400 Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2

Masuda, S, Terada, T, Yonezawa, A, Tanihara, Y, Kishimoto, K, Katsura, T, Ogawa, O, Inui, K

J Am Soc Nephrol 2006
17509534 Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters

Tanihara, Y, Masuda, S, Sato, T, Katsura, T, Ogawa, O, Inui, K

Biochem Pharmacol 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
solute:proton antiporter activity of MATE1/2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!