Reactome | MATEs mediate extrusion of xenobiotics

MATEs mediate extrusion of xenobiotics

Stable Identifier

R-HSA-434650

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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The human gene family SLC47 encodes 2 multidrug and toxin extrusion (MATE) proteins. Mammalian MATE-type transporters are responsible for the final step in the excretion of metabolic waste and xenobiotic organic cations in the kidney and liver through electroneutral exchange of H(+).
MATE1 is primarily expressed in the kidney and liver, where it is localized to the luminal membranes of the urinary tubules and bile canaliculi. When expressed in HEK293 cells, MATE1 mediates H(+)-coupled electroneutral exchange of various drugs (Otsuka M et al, 2005). MATE2 is a human kidney-specific H+/organic cation antiporter that is responsible for the tubular secretion of cationic drugs across the brush border membranes (Masuda S et al, 2006). Substrates for both MATEs include tetraethylammonium, 1-methyl-4-phenylpyridinium, cimetidine, metformin, creatinine, guanidine and procainamide (Tanihara Y et al, 2007).

Literature References

PubMed ID	Title	Journal	Year
16807400	Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2 Masuda, S, Terada, T, Yonezawa, A, Tanihara, Y, Kishimoto, K, Katsura, T, Ogawa, O, Inui, K	J Am Soc Nephrol	2006
16330770	A human transporter protein that mediates the final excretion step for toxic organic cations Otsuka, M, Matsumoto, T, Morimoto, R, Arioka, S, Omote, H, Moriyama, Y	Proc Natl Acad Sci U S A	2005
17509534	Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters Tanihara, Y, Masuda, S, Sato, T, Katsura, T, Ogawa, O, Inui, K	Biochem Pharmacol	2007