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E2F1 binds PMAIP1 (NOXA) promoter
Stable Identifier
R-HSA-4331327
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Activation of BH3-only proteins (Homo sapiens)
Activation of NOXA and translocation to mitochondria (Homo sapiens)
E2F1 binds PMAIP1 (NOXA) promoter (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
E2F1, in complex with TFDP1 (DP-1), binds the promoter of PMAIP1 (NOXA) gene (Hershko and Ginsberg 2004).
Literature References
PubMed ID
Title
Journal
Year
14684737
Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis
Hershko, T
,
Ginsberg, D
J Biol Chem
2004
Participants
Input
E2F1:TFDP1,TFDP2 [nucleoplasm]
(Homo sapiens)
PMAIP1 Gene [nucleoplasm]
(Homo sapiens)
Output
E2F1:TFDP1:PMAIP1 Gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Activation of NOXA and translocation to mitochondria (Homo sapiens)
Authored
Orlic-Milacic, M (2013-08-15)
Created
Orlic-Milacic, M (2013-08-16)
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