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GP1b-IX-V activation signalling
Stable Identifier
R-HSA-430116
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GP1b-IX-V activation signalling (Homo sapiens)
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The platelet GPIb complex (GP1b-IX-V) together with GPVI are primarily responsible for regulating the initial adhesion of platelets to the damaged blood vessel and platelet activation. The importance of GPIb is demonstrated by the bleeding problems in patients with Bernard-Soulier syndrome where this receptor is either absent or defective. GP1b-IX-V binds von Willebrand Factor (vWF) to resting platelets, particularly under conditions of high shear stress. This transient interaction is the first stage of the vascular repair process. Activation of GP1b-IX-V on exposure of the fibrous matrix following atherosclerotic plaque rupture, or in occluded arteries, is a major contributory factor leading to thrombus formation leading to heart attack or stroke. GpIb also binds thrombin (Yamamoto et al. 1986), at a site distinct from the site of vWF binding, acting as a docking site for thrombin which then activates Proteinase Activated Receptors leading to enhanced platelet activation (Dormann et al. 2000).
Literature References
PubMed ID
Title
Journal
Year
15507277
Platelet physiology and thrombosis
Berndt, MC
,
Andrews, RK
Thromb Res
2004
17585075
Adhesion mechanisms in platelet function
Ruggeri, ZM
,
Mendolicchio, GL
Circ Res
2007
Participants
Events
vWF binds to collagen
(Homo sapiens)
GPIb-IX-V binds to vWF:Collagen complex
(Homo sapiens)
GP1b-IX-V binds 14-3-3-zeta
(Homo sapiens)
GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress
(Homo sapiens)
GP1b-IX-V binds filamin
(Homo sapiens)
GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K
(Homo sapiens)
GP1b signaling involves c-Src
(Homo sapiens)
c-Src binds Raf1
(Homo sapiens)
14-3-3-zeta binds Raf1
(Homo sapiens)
Participates
as an event of
Platelet activation, signaling and aggregation (Homo sapiens)
Orthologous Events
GP1b-IX-V activation signalling (Bos taurus)
GP1b-IX-V activation signalling (Caenorhabditis elegans)
GP1b-IX-V activation signalling (Canis familiaris)
GP1b-IX-V activation signalling (Danio rerio)
GP1b-IX-V activation signalling (Drosophila melanogaster)
GP1b-IX-V activation signalling (Gallus gallus)
GP1b-IX-V activation signalling (Mus musculus)
GP1b-IX-V activation signalling (Plasmodium falciparum)
GP1b-IX-V activation signalling (Rattus norvegicus)
GP1b-IX-V activation signalling (Sus scrofa)
GP1b-IX-V activation signalling (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000940
Authored
Akkerman, JW (2009-06-03)
Reviewed
Kunapuli, SP (2010-06-07)
Created
Jupe, S (2009-07-30)
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