Reactome | PAN2-PAN3 complex partially deadenylates mRNA

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PAN2-PAN3 complex partially deadenylates mRNA Show undefined attributes

authored	[InstanceEdit:430015] May, B, 2009-07-22
catalystActivity	[CatalystActivity:429943] poly(A)-specific ribonuclease activity of PAN2-PAN3 Complex [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:429836] May, B, 2009-07-23
dbId	430021
displayName	PAN2-PAN3 complex partially deadenylates mRNA
edited	[InstanceEdit:430015] May, B, 2009-07-22
eventOf	[Pathway:R-HSA-429947] Deadenylation of mRNA - Homo sapiens
followingEvent	[Reaction:R-HSA-8941312] TUT4,TUT7 oligouridylate mRNA - Homo sapiens [Reaction:R-HSA-429992] PARN deadenylates mRNA - Homo sapiens [Reaction:R-HSA-429955] CCR4-NOT complex deadenylates mRNA - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-HSA-429977] Translatable mRNA Complex [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:433080] Identification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding protein [LiteratureReference:429831] Poly(A) nuclease interacts with the C-terminal domain of polyadenylate-binding protein domain from poly(A)-binding protein [LiteratureReference:429957] The highways and byways of mRNA decay [LiteratureReference:429884] Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover [LiteratureReference:429929] Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells [LiteratureReference:429946] Messenger RNA decay in mammalian cells: the exonuclease perspective [LiteratureReference:429954] The many pathways of RNA degradation [LiteratureReference:430040] From birth to death: the complex lives of eukaryotic mRNAs [LiteratureReference:429833] The enzymes and control of eukaryotic mRNA turnover [LiteratureReference:430007] The cap-to-tail guide to mRNA turnover
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	PAN2-PAN3 complex partially deadenylates mRNA
orthologousEvent	[Reaction:R-SCE-430021] PAN2-PAN3 complex partially deadenylates mRNA - Saccharomyces cerevisiae [Reaction:R-SPO-430021] PAN2-PAN3 complex partially deadenylates mRNA - Schizosaccharomyces pombe [Reaction:R-DME-430021] PAN2-PAN3 complex partially deadenylates mRNA - Drosophila melanogaster [Reaction:R-GGA-430021] PAN2-PAN3 complex partially deadenylates mRNA - Gallus gallus [Reaction:R-SSC-430021] PAN2-PAN3 complex partially deadenylates mRNA - Sus scrofa [Reaction:R-BTA-430021] PAN2-PAN3 complex partially deadenylates mRNA - Bos taurus [Reaction:R-CFA-430021] PAN2-PAN3 complex partially deadenylates mRNA - Canis familiaris [Reaction:R-RNO-430021] PAN2-PAN3 complex partially deadenylates mRNA - Rattus norvegicus [Reaction:R-MMU-430021] PAN2-PAN3 complex partially deadenylates mRNA - Mus musculus
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [Complex:R-HSA-429989] Partially Deadenylated mRNA Complex [cytosol]
precedingEvent	[Reaction:R-HSA-75098] mRNP complex dissociates from cytosolic face of NPC - Homo sapiens
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:442431] Wilusz, J, 2009-09-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-430021
summation	[Summation:429907] The PAN2-PAN3 exoribonuclease complex hydrolyzes the poly(A)...

Referrals

(precedingEvent)	[Reaction:R-HSA-8941312] TUT4,TUT7 oligouridylate mRNA [Reaction:R-HSA-429992] PARN deadenylates mRNA [Reaction:R-HSA-429955] CCR4-NOT complex deadenylates mRNA
(hasEvent)	[Pathway:R-HSA-429947] Deadenylation of mRNA

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