Reactome | DCP1-DCP2 complex decaps mRNA

DCP1-DCP2 complex decaps mRNA

Stable Identifier

R-HSA-429860

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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The DCP1-DCP2 decapping complex binds the 7-methylguanosine cap of mRNA and hydrolyzes the triphosphate bond to yield 7-methylguanosine 5'-diphosphate and RNA with 5'-monophosphate. The DCP2 subunit of the complex catalyzes the hydrolysis. DCP2 has higher affinity for some subsets of mRNA.

Literature References

PubMed ID	Title	Journal	Year
16141059	From birth to death: the complex lives of eukaryotic mRNAs Moore, MJ	Science	2005
15475613	Messenger RNA decay in mammalian cells: the exonuclease perspective Fritz, DT, Bergman, N, Kilpatrick, WJ, Wilusz, CJ, Wilusz, J	Cell Biochem Biophys	2004
16246173	Decapping the message: a beginning or an end Liu, H, Kiledjian, M	Biochem Soc Trans	2006
15085179	Poly(A)-binding-protein-mediated regulation of hDcp2 decapping in vitro Khanna, R, Kiledjian, M	EMBO J	2004
12486012	Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures van Dijk, E, Cougot, N, Meyer, S, Babajko, S, Wahle, E, Séraphin, B	EMBO J	2002
11283721	The cap-to-tail guide to mRNA turnover Wilusz, CJ, Wormington, M, Peltz, SW	Nat Rev Mol Cell Biol	2001
14749774	The enzymes and control of eukaryotic mRNA turnover Parker, R, Song, H	Nat Struct Mol Biol	2004
12923261	Functional characterization of the mammalian mRNA decapping enzyme hDcp2 Piccirillo, C, Khanna, R, Kiledjian, M	RNA	2003
12218187	The hDcp2 protein is a mammalian mRNA decapping enzyme Wang, Z, Jiao, X, Carr-Schmid, A, Kiledjian, M	Proc Natl Acad Sci U S A	2002
12417715	Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay Lykke-Andersen, J	Mol Cell Biol	2002
18039849	Transcript-specific decapping and regulated stability by the human Dcp2 decapping protein Li, Y, Song, MG, Kiledjian, M	Mol Cell Biol	2008
19239894	The many pathways of RNA degradation Houseley, J, Tollervey, D	Cell	2009
17245413	The highways and byways of mRNA decay Garneau, NL, Wilusz, J, Wilusz, CJ	Nat Rev Mol Cell Biol	2007
19061636	The control of mRNA decapping and P-body formation Franks, TM, Lykke-Andersen, J	Mol Cell	2008