DCP1-DCP2 complex decaps mRNA

Stable Identifier
Reaction [transition]
Homo sapiens
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The DCP1-DCP2 decapping complex binds the 7-methylguanosine cap of mRNA and hydrolyzes the triphosphate bond to yield 7-methylguanosine 5'-diphosphate and RNA with 5'-monophosphate. The DCP2 subunit of the complex catalyzes the hydrolysis. DCP2 has higher affinity for some subsets of mRNA.

Literature References
PubMed ID Title Journal Year
16141059 From birth to death: the complex lives of eukaryotic mRNAs

Moore, MJ

Science 2005
15475613 Messenger RNA decay in mammalian cells: the exonuclease perspective

Fritz, DT, Wilusz, J, Bergman, N, Wilusz, CJ, Kilpatrick, WJ

Cell Biochem Biophys 2004
16246173 Decapping the message: a beginning or an end

Kiledjian, M, Liu, H

Biochem Soc Trans 2006
15085179 Poly(A)-binding-protein-mediated regulation of hDcp2 decapping in vitro

Kiledjian, M, Khanna, R

EMBO J 2004
12486012 Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures

Cougot, N, Séraphin, B, Meyer, S, van Dijk, E, Babajko, S, Wahle, E

EMBO J 2002
11283721 The cap-to-tail guide to mRNA turnover

Wormington, M, Wilusz, CJ, Peltz, SW

Nat Rev Mol Cell Biol 2001
14749774 The enzymes and control of eukaryotic mRNA turnover

Song, H, Parker, R

Nat Struct Mol Biol 2004
12923261 Functional characterization of the mammalian mRNA decapping enzyme hDcp2

Kiledjian, M, Khanna, R, Piccirillo, C

RNA 2003
12218187 The hDcp2 protein is a mammalian mRNA decapping enzyme

Wang, Z, Jiao, X, Kiledjian, M, Carr-Schmid, A

Proc Natl Acad Sci U S A 2002
12417715 Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay

Lykke-Andersen, J

Mol Cell Biol 2002
18039849 Transcript-specific decapping and regulated stability by the human Dcp2 decapping protein

Song, MG, Kiledjian, M, Li, Y

Mol Cell Biol 2008
19239894 The many pathways of RNA degradation

Houseley, J, Tollervey, D

Cell 2009
17245413 The highways and byways of mRNA decay

Garneau, NL, Wilusz, J, Wilusz, CJ

Nat Rev Mol Cell Biol 2007
19061636 The control of mRNA decapping and P-body formation

Franks, TM, Lykke-Andersen, J

Mol Cell 2008
Catalyst Activity

exoribonuclease activity, producing 5'-phosphomonoesters of DCP1-DCP2 Decapping Complex [cytosol]

Orthologous Events
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