Reactome | SGMS1 transfers phosphocholine onto ceramide

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SGMS1 transfers phosphocholine onto ceramide Show undefined attributes

catalystActivity	[CatalystActivity:10585457] sphingomyelin synthase activity of SGMS1 [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10585459
displayName	SGMS1 transfers phosphocholine onto ceramide
eventOf	[Pathway:R-DRE-1660661] Sphingolipid de novo biosynthesis - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-429798] SGMS1 transfers phosphocholine onto ceramide - Homo sapiens
input	[SimpleEntity:R-ALL-428270] CERA [Golgi membrane] [SimpleEntity:R-ALL-429785] PC [Golgi membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	SGMS1 transfers phosphocholine onto ceramide phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1]
output	[SimpleEntity:R-ALL-1524057] DAG [Golgi membrane] [SimpleEntity:R-ALL-429789] SPHM [Golgi membrane]
precedingEvent	[Reaction:R-DRE-9956909] CERT1-2 transfers CERA from the ER membrane to the Golgi membrane - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-429798
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-1660661] Sphingolipid de novo biosynthesis
(inferredTo)	[Reaction:R-HSA-429798] SGMS1 transfers phosphocholine onto ceramide

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