Reactome | SGMS1 transfers phosphocholine onto ceramide

SGMS1 transfers phosphocholine onto ceramide

Stable Identifier

R-HSA-429798

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1]

ReviewStatus

5/5

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SGMS1 transfers phosphocholine onto ceramide

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SGMS1 (sphingomyelin synthase 1) associated with the membrane of the Golgi apparatus catalyzes the reversible reaction of phosphatidylcholine and ceramide to form sphingomyelin and diacylglycerol. Phosphatidylcholine was identified as the source of the phosphocholine moiety donated to ceramide in this reaction in studies of the mouse enzyme in the 1970s (Diringer et al. 1972; Ullman and Radin 1974). SGMS1 is widely expressed in the body, and studies of cultured cells indicate that this reaction provides the primary source of cellular sphingomyelin (Yamaoka et al., 2004; Huitema et al., 2004; Tafesse et al., 2007; reviewed by Chen & Cao, 2017).

Literature References

PubMed ID	Title	Journal	Year
28742512	The sphingomyelin synthase family: proteins, diseases, and inhibitors Chen, Y, Cao, Y	Biol Chem	2017
4817756	The enzymatic formation of sphingomyelin from ceramide and lecithin in mouse liver Ullman, MD, Radin, NS	J Biol Chem	1974
4339164	Evidence for a new biosynthetic pathway of sphingomyelin in SV 40 transformed mouse cells Diringer, H, Marggraf, WD, Koch, MA, Anderer, FA	Biochem Biophys Res Commun	1972
17449912	Both sphingomyelin synthases SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells Tafesse, FG, Huitema, K, Hermansson, M, van der Poel, S, van den Dikkenberg, J, Uphoff, A, Somerharju, P, Holthuis, JC	J Biol Chem	2007
14976195	Expression cloning of a human cDNA restoring sphingomyelin synthesis and cell growth in sphingomyelin synthase-defective lymphoid cells Yamaoka, S, Miyaji, M, Kitano, T, Umehara, H, Okazaki, T	J Biol Chem	2004
14685263	Identification of a family of animal sphingomyelin synthases Huitema, K, van den Dikkenberg, J, Brouwers, JF, Holthuis, JC	EMBO J	2004