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Reaction
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Entries
SGPP1,2 dephosphorylate sphingoid-1-phosphates
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authored
[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
catalystActivity
[CatalystActivity:428700] sphingosine-1-phosphate phosphatase activity of SGPP [endoplasmic reticulum membrane]
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created
[InstanceEdit:428672] D'Eustachio, P, 2009-07-06
crossReference
[DatabaseIdentifier:12667865] RHEA:63952
dbId
428664
deleted
[Deleted:9949971] Deletion of instance: 428701
[Deleted:9851912] Deletion of instance: 428701
[Deleted:9852820] Deletion of instance: 428701
displayName
SGPP1,2 dephosphorylate sphingoid-1-phosphates
edited
[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
eventOf
[Pathway:R-HSA-9845614] Sphingolipid catabolism - Homo sapiens
input
[SimpleEntity:R-ALL-29356] H2O [cytosol]
[SimpleEntity:R-ALL-5279322] S1P [cytoplasm]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:428659] Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2
[LiteratureReference:428678] Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability
[LiteratureReference:9844177] Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide
maxDepth
1
modified
[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name
SGPP1,2 dephosphorylate sphingoid-1-phosphates
sphinganine 1-phosphate + H2O => sphinganine + orthophosphate
orthologousEvent
[Reaction:R-SCE-428664] SGPP1,2 dephosphorylate sphingoid-1-phosphates - Saccharomyces cerevisiae
[Reaction:R-SPO-428664] SGPP1,2 dephosphorylate sphingoid-1-phosphates - Schizosaccharomyces pombe
[Reaction:R-DDI-428664] SGPP1,2 dephosphorylate sphingoid-1-phosphates - Dictyostelium discoideum
[Reaction:R-GGA-428664] SGPP1,2 dephosphorylate sphingoid-1-phosphates - Gallus gallus
[Reaction:R-XTR-428664] SGPP1,2 dephosphorylate sphingoid-1-phosphates - Xenopus tropicalis
[Reaction:R-DRE-428664] SGPP1,2 dephosphorylate sphingoid-1-phosphates - Danio rerio
[Reaction:R-SSC-428664] SGPP1,2 dephosphorylate sphingoid-1-phosphates - Sus scrofa
[Reaction:R-BTA-428664] SGPP1,2 dephosphorylate sphingoid-1-phosphates - Bos taurus
[Reaction:R-CFA-428664] SGPP1,2 dephosphorylate sphingoid-1-phosphates - Canis familiaris
[Reaction:R-RNO-428664] SGPP1,2 dephosphorylate sphingoid-1-phosphates - Rattus norvegicus
[Reaction:R-MMU-428664] SGPP1,2 dephosphorylate sphingoid-1-phosphates - Mus musculus
output
[SimpleEntity:R-ALL-29372] Pi [cytosol]
[SimpleEntity:R-ALL-428682] SPG [cytosol]
precedingEvent
[Reaction:R-HSA-428273] SPHK1 phosphorylates sphingoid - Homo sapiens
[Reaction:R-HSA-9695949] SPHK2 phosphorylates sphingoid - Homo sapiens
releaseDate
2009-09-30
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:446905] Hannun, YA, Luberto, C, 2009-11-18
[InstanceEdit:433039] Jassal, B, 2009-08-20
[InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-428664
summation
[Summation:428683] SGPP1 and 2 (sphingosine-1-phosphate phosphatase 1 and 2) en...
updateTrackers
[UpdateTracker:9853266] Update Tracker - [Reaction:428664] SGPP1,2 dephosphorylate sphingoid-1-phosphates - v87:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
[UpdateTracker:9864000] Update Tracker - [Reaction:428664] SGPP1,2 dephosphorylate sphingoid-1-phosphates - v88:[add_removeCatalystActivity]
Referrals
(updatedInstance)
[UpdateTracker:9853266] Update Tracker - [Reaction:428664] SGPP1,2 dephosphorylate sphingoid-1-phosphates - v87:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
[UpdateTracker:9864000] Update Tracker - [Reaction:428664] SGPP1,2 dephosphorylate sphingoid-1-phosphates - v88:[add_removeCatalystActivity]
(replacementInstances)
[Deleted:9949971] Deletion of instance: 428701
[Deleted:9851912] Deletion of instance: 428701
[Deleted:9852820] Deletion of instance: 428701
(hasEvent)
[Pathway:R-HSA-9845614] Sphingolipid catabolism
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