SPHK1 phosphorylates SPG to S1P

Stable Identifier
R-HSA-428273
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The cytosolic enzyme sphingosine kinase 1 (SPHK1) catalyzes the phosphorylation of sphingosine (SPG) to sphingosine 1-phosphate (S1P) (Nava et al. 2000, Pitson et al. 2000).

Literature References
PubMed ID Title Journal Year
10947957 Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes

Pitson, SM, D'Andrea, RJ, Vandeleur, L, Moretti, PA, Xia, P, Gamble, JR, Vadas, MA, Wattenberg, BW

Biochem J 2000
10802064 Functional characterization of human sphingosine kinase-1

Nava, VE, Lacana, E, Poulton, S, Liu, H, Sugiura, M, Kono, K, Milstien, S, Kohama, T, Spiegel, S

FEBS Lett 2000
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Catalyst Activity

D-erythro-sphingosine kinase activity of SPHK1 [cytosol]

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