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ACER2 hydrolyzes ceramide (Golgi)
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authored
[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
catalystActivity
[CatalystActivity:428257] N-acylsphingosine amidohydrolase activity of ACER2 [Golgi membrane]
category
transition
compartment
[Compartment:20699] Golgi membrane
[Compartment:70101] cytosol
created
[InstanceEdit:428277] D'Eustachio, P, 2009-07-03
dbId
428205
displayName
ACER2 hydrolyzes ceramide (Golgi)
edited
[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
eventOf
[Pathway:R-HSA-9845614] Sphingolipid catabolism - Homo sapiens
input
[SimpleEntity:R-ALL-428270] CERA [Golgi membrane]
[SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:428268] Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P
[LiteratureReference:9843845] Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate
[LiteratureReference:9843863] Elusive Roles of the Different Ceramidases in Human Health, Pathophysiology, and Tissue Regeneration
[LiteratureReference:9843856] Role of Ceramidases in Sphingolipid Metabolism and Human Diseases
[LiteratureReference:9843875] Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2)
[LiteratureReference:9843851] Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2
[LiteratureReference:9844129] Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols
modified
[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name
ACER2 hydrolyzes ceramide (Golgi)
ceramide + H2O => fatty acid + sphingosine (Golgi)
orthologousEvent
[Reaction:R-CEL-428205] ACER2 hydrolyzes ceramide (Golgi) - Caenorhabditis elegans
[Reaction:R-DME-428205] ACER2 hydrolyzes ceramide (Golgi) - Drosophila melanogaster
[Reaction:R-GGA-428205] ACER2 hydrolyzes ceramide (Golgi) - Gallus gallus
[Reaction:R-XTR-428205] ACER2 hydrolyzes ceramide (Golgi) - Xenopus tropicalis
[Reaction:R-SSC-428205] ACER2 hydrolyzes ceramide (Golgi) - Sus scrofa
[Reaction:R-BTA-428205] ACER2 hydrolyzes ceramide (Golgi) - Bos taurus
[Reaction:R-CFA-428205] ACER2 hydrolyzes ceramide (Golgi) - Canis familiaris
[Reaction:R-RNO-428205] ACER2 hydrolyzes ceramide (Golgi) - Rattus norvegicus
[Reaction:R-MMU-428205] ACER2 hydrolyzes ceramide (Golgi) - Mus musculus
output
[SimpleEntity:R-ALL-1861754] RCOO- [cytosol]
[SimpleEntity:R-ALL-428682] SPG [cytosol]
precedingEvent
[Reaction:R-HSA-429683] CERT1-2 releases its bound ceramide into the membrane of the Golgi apparatus - Homo sapiens
releaseDate
2009-09-30
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:446905] Hannun, YA, Luberto, C, 2009-11-18
[InstanceEdit:433039] Jassal, B, 2009-08-20
[InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-428205
summation
[Summation:428243] ACER2 (alkaline ceramidase 2), associated with the membrane ...
Referrals
(hasEvent)
[Pathway:R-HSA-9845614] Sphingolipid catabolism
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