Reactome | ACER2 hydrolyzes ceramide (Golgi)

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ACER2 hydrolyzes ceramide (Golgi) Show undefined attributes

authored	[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
catalystActivity	[CatalystActivity:428257] N-acylsphingosine amidohydrolase activity of ACER2 [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:70101] cytosol
created	[InstanceEdit:428277] D'Eustachio, P, 2009-07-03
crossReference	[DatabaseIdentifier:12667857] RHEA:78455
dbId	428205
displayName	ACER2 hydrolyzes ceramide (Golgi)
edited	[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
eventOf	[Pathway:R-HSA-9845614] Sphingolipid catabolism - Homo sapiens
input	[SimpleEntity:R-ALL-428270] CERA [Golgi membrane] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:428268] Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P [LiteratureReference:9843845] Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate [LiteratureReference:9843863] Elusive Roles of the Different Ceramidases in Human Health, Pathophysiology, and Tissue Regeneration [LiteratureReference:9843856] Role of Ceramidases in Sphingolipid Metabolism and Human Diseases [LiteratureReference:9843875] Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2) [LiteratureReference:9843851] Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2 [LiteratureReference:9844129] Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	ACER2 hydrolyzes ceramide (Golgi) ceramide + H2O => fatty acid + sphingosine (Golgi)
orthologousEvent	[Reaction:R-CEL-428205] ACER2 hydrolyzes ceramide (Golgi) - Caenorhabditis elegans [Reaction:R-DME-428205] ACER2 hydrolyzes ceramide (Golgi) - Drosophila melanogaster [Reaction:R-GGA-428205] ACER2 hydrolyzes ceramide (Golgi) - Gallus gallus [Reaction:R-XTR-428205] ACER2 hydrolyzes ceramide (Golgi) - Xenopus tropicalis [Reaction:R-DRE-428205] ACER2 hydrolyzes ceramide (Golgi) - Danio rerio [Reaction:R-SSC-428205] ACER2 hydrolyzes ceramide (Golgi) - Sus scrofa [Reaction:R-BTA-428205] ACER2 hydrolyzes ceramide (Golgi) - Bos taurus [Reaction:R-CFA-428205] ACER2 hydrolyzes ceramide (Golgi) - Canis familiaris [Reaction:R-RNO-428205] ACER2 hydrolyzes ceramide (Golgi) - Rattus norvegicus [Reaction:R-MMU-428205] ACER2 hydrolyzes ceramide (Golgi) - Mus musculus
output	[SimpleEntity:R-ALL-1861754] RCOO- [cytosol] [SimpleEntity:R-ALL-428682] SPG [cytosol]
precedingEvent	[Reaction:R-HSA-9956909] CERT1-2 transfers CERA from the ER membrane to the Golgi membrane - Homo sapiens
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:446905] Hannun, YA, Luberto, C, 2009-11-18 [InstanceEdit:433039] Jassal, B, 2009-08-20 [InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-428205
summation	[Summation:428243] ACER2 (alkaline ceramidase 2), associated with the membrane ...
updateTrackers	[UpdateTracker:9782703] Update Tracker - [Reaction:428205] ceramide + H2O => stearate + sphingosine [Golgi] - v58:[add_removeOutput] [UpdateTracker:9853270] Update Tracker - [Reaction:428205] ACER2 hydrolyzes ceramide (Golgi) - v87:[addLiteratureReference, add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9782703] Update Tracker - [Reaction:428205] ceramide + H2O => stearate + sphingosine [Golgi] - v58:[add_removeOutput] [UpdateTracker:9853270] Update Tracker - [Reaction:428205] ACER2 hydrolyzes ceramide (Golgi) - v87:[addLiteratureReference, add_removeOutput, modifyText]
(hasEvent)	[Pathway:R-HSA-9845614] Sphingolipid catabolism

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