ACER2 (alkaline ceramidase 2), associated with the membrane ...

created [InstanceEdit:428277] D'Eustachio, P, 2009-07-03
dbId 428243
displayName ACER2 (alkaline ceramidase 2), associated with the membrane ...
modified [InstanceEdit:9844143] Stephan, Ralf, 2023-09-13
schemaClass Summation
text ACER2 (alkaline ceramidase 2), associated with the membrane of the Golgi apparatus, catalyzes the hydrolysis of ceramide to yield a free fatty acid and sphingosine. ACER2 hydrolyses ceramides and dihydroceramides C18:1 and C20:1 (Casasampere et al., 2015). ACER2 mRNA is widely expressed in the body, although only at low levels except in the placenta (Xu et al., 2006; Sun et al., 2010; Xu et al., 2018). ACER2 expression is regulated by the tumor suppressor p53 and endothelial PAS domain-containing protein 1 (EPAS1, hypoxia-inducible factor HIF2A) (reviewed by Mao & Obeid, 2008; Parveen et al., 2019; Duarte et al., 2020).
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