Reactome | ACER2 hydrolyzes ceramide (Golgi)

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ACER2 hydrolyzes ceramide (Golgi) Show undefined attributes

catalystActivity	[CatalystActivity:10255882] N-acylsphingosine amidohydrolase activity of ACER2 [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10255884
displayName	ACER2 hydrolyzes ceramide (Golgi)
eventOf	[Pathway:R-CFA-9845614] Sphingolipid catabolism - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-428205] ACER2 hydrolyzes ceramide (Golgi) - Homo sapiens
input	[SimpleEntity:R-ALL-428270] CERA [Golgi membrane] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ACER2 hydrolyzes ceramide (Golgi) ceramide + H2O => fatty acid + sphingosine (Golgi)
output	[SimpleEntity:R-ALL-1861754] RCOO- [cytosol] [SimpleEntity:R-ALL-428682] SPG [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-428205
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-9845614] Sphingolipid catabolism
(inferredTo)	[Reaction:R-HSA-428205] ACER2 hydrolyzes ceramide (Golgi)

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