Reactome | Cleavage of the signal peptide of Preproghrelin

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Cleavage of the signal peptide of Preproghrelin Show undefined attributes

authored	[InstanceEdit:426529] May, B, 2009-06-10
catalystActivity	[CatalystActivity:265014] serine-type endopeptidase activity of Signal Peptidase [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:422063] May, B, 2009-05-25 21:41:39
dbId	422051
displayName	Cleavage of the signal peptide of Preproghrelin
edited	[InstanceEdit:426529] May, B, 2009-06-10
eventOf	[Pathway:R-HSA-422085] Synthesis, secretion, and deacylation of Ghrelin - Homo sapiens
followingEvent	[Reaction:R-HSA-422104] Ghrelin O-acyltransferase octanoylates Proghrelin - Homo sapiens [Reaction:R-HSA-422017] Ghrelin O-acyltransferase decanoylates Proghrelin - Homo sapiens
input	[DefinedSet:R-HSA-422026] Preproghrelin and prepro-des-Gln14-ghrelin [endoplasmic reticulum lumen]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:422105] Ghrelin fluctuation, what determines its production? [LiteratureReference:422095] Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Cleavage of the signal peptide of Preproghrelin
orthologousEvent	[Reaction:R-GGA-422051] Cleavage of the signal peptide of Preproghrelin - Gallus gallus [Reaction:R-DRE-422051] Cleavage of the signal peptide of Preproghrelin - Danio rerio [Reaction:R-SSC-422051] Cleavage of the signal peptide of Preproghrelin - Sus scrofa [Reaction:R-BTA-422051] Cleavage of the signal peptide of Preproghrelin - Bos taurus [Reaction:R-CFA-422051] Cleavage of the signal peptide of Preproghrelin - Canis familiaris [Reaction:R-RNO-422051] Cleavage of the signal peptide of Preproghrelin - Rattus norvegicus [Reaction:R-MMU-422051] Cleavage of the signal peptide of Preproghrelin - Mus musculus
output	[DefinedSet:R-HSA-422091] Proghrelin and Pro-des-Gln14-ghrelin [endoplasmic reticulum lumen]
precedingEvent	[BlackBoxEvent:R-HSA-422088] Expression of Preproghrelin - Homo sapiens
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:434405] Zhang, Weizhen, 2009-08-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-422051
summation	[Summation:422072] The N-terminal 23 amino acid residues are cleaved from prepr...

Referrals

(hasEvent)	[Pathway:R-HSA-422085] Synthesis, secretion, and deacylation of Ghrelin
(precedingEvent)	[Reaction:R-HSA-422104] Ghrelin O-acyltransferase octanoylates Proghrelin [Reaction:R-HSA-422017] Ghrelin O-acyltransferase decanoylates Proghrelin