Reactome | Expression of Preproghrelin

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Expression of Preproghrelin Show undefined attributes

authored	[InstanceEdit:426529] May, B, 2009-06-10
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:422063] May, B, 2009-05-25 21:41:39
dbId	422088
displayName	Expression of Preproghrelin
edited	[InstanceEdit:426529] May, B, 2009-06-10
eventOf	[Pathway:R-HSA-422085] Synthesis, secretion, and deacylation of Ghrelin - Homo sapiens
followingEvent	[Reaction:R-HSA-422051] Cleavage of the signal peptide of Preproghrelin - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5652756] GHRL gene [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:538960] Ghrelin is a growth-hormone-releasing acylated peptide from stomach [LiteratureReference:538974] The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans [LiteratureReference:434552] Characterization and regulation of the rat and human ghrelin promoters [LiteratureReference:434550] Genomic structure and characterization of the 5'-flanking region of the human ghrelin gene [LiteratureReference:434459] KLF4 positively regulates human ghrelin expression [LiteratureReference:422105] Ghrelin fluctuation, what determines its production? [LiteratureReference:422095] Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Expression of Preproghrelin
output	[DefinedSet:R-HSA-422026] Preproghrelin and prepro-des-Gln14-ghrelin [endoplasmic reticulum lumen]
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-434462] Positive gene expression regulation by 'KLF4 [nucleoplasm]' [NegativeGeneExpressionRegulation:R-HSA-8931572] Negative gene expression regulation by 'CRHR2:UCN(83-122) [plasma membrane]'
regulationReference	[RegulationReference:9641730] Negative gene expression regulation by 'CRHR2:UCN(83-122) [plasma membrane]' Urocortin 1 reduces food intake and ghrelin secretion via CRF(2) receptors [RegulationReference:9641982] Positive gene expression regulation by 'KLF4 [nucleoplasm]' KLF4 positively regulates human ghrelin expression
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:434405] Zhang, Weizhen, 2009-08-29
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-422088
summation	[Summation:422049] The ghrelin gene is transcribed and spliced to yield two var... [Summation:8933559] As inferred from rat homologues, Urocortin (UCN) binds the C...
updateTrackers	[UpdateTracker:9785434] Update Tracker - [BlackBoxEvent:422088] Expression of Preproghrelin - v52:[addInput] [UpdateTracker:9790545] Update Tracker - [BlackBoxEvent:422088] Expression of Preproghrelin - v33:[addLiteratureReference] [UpdateTracker:9782940] Update Tracker - [BlackBoxEvent:422088] Expression of Preproghrelin - v58:[addRegulator] [UpdateTracker:9776059] Update Tracker - [BlackBoxEvent:422088] Expression of Preproghrelin - v78:[addSummation]

Referrals

(updatedInstance)	[UpdateTracker:9785434] Update Tracker - [BlackBoxEvent:422088] Expression of Preproghrelin - v52:[addInput] [UpdateTracker:9790545] Update Tracker - [BlackBoxEvent:422088] Expression of Preproghrelin - v33:[addLiteratureReference] [UpdateTracker:9782940] Update Tracker - [BlackBoxEvent:422088] Expression of Preproghrelin - v58:[addRegulator] [UpdateTracker:9776059] Update Tracker - [BlackBoxEvent:422088] Expression of Preproghrelin - v78:[addSummation]
(hasEvent)	[Pathway:R-HSA-422085] Synthesis, secretion, and deacylation of Ghrelin
(precedingEvent)	[Reaction:R-HSA-422051] Cleavage of the signal peptide of Preproghrelin

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