Cleavage of the signal peptide of Preproghrelin

Stable Identifier
R-HSA-422051
Type
Reaction
Species
Homo sapiens
Compartment
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The N-terminal 23 amino acid residues are cleaved from preproghrelin by the signal peptidase complex. The products are proghrelin (94 amino acid residues) or des-acyl-Gln14 proghrelin (93 amino acid residues), depending on the variant of the mRNA that was translated.

Literature References
PubMed ID Title Journal Year
19280057 Ghrelin fluctuation, what determines its production?

Yin, X, Li, Y, Zhang, W, An, W, Xu, G

Acta Biochim Biophys Sin (Shanghai) 2009
18396350 Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle

Soares, JB, Leite-Moreira, AF

Peptides 2008
Participants
Participates
Catalyst Activity

serine-type endopeptidase activity of Signal Peptidase [endoplasmic reticulum membrane]

Orthologous Events
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