Reactome | Cleavage of the signal peptide of Preproghrelin

Schema > Reaction > Entries

Cleavage of the signal peptide of Preproghrelin Show undefined attributes

catalystActivity	[CatalystActivity:10757840] serine-type endopeptidase activity of Signal Peptidase [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10757842
displayName	Cleavage of the signal peptide of Preproghrelin
eventOf	[Pathway:R-GGA-422085] Synthesis, secretion, and deacylation of Ghrelin - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-422104] Ghrelin O-acyltransferase octanoylates Proghrelin - Gallus gallus [Reaction:R-GGA-422017] Ghrelin O-acyltransferase decanoylates Proghrelin - Gallus gallus
inferredFrom	[Reaction:R-HSA-422051] Cleavage of the signal peptide of Preproghrelin - Homo sapiens
input	[EntityWithAccessionedSequence:R-GGA-422044] GHRL [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	Cleavage of the signal peptide of Preproghrelin
output	[EntityWithAccessionedSequence:R-GGA-422090] GHRL [endoplasmic reticulum lumen]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-422051
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-422085] Synthesis, secretion, and deacylation of Ghrelin
(precedingEvent)	[Reaction:R-GGA-422104] Ghrelin O-acyltransferase octanoylates Proghrelin [Reaction:R-GGA-422017] Ghrelin O-acyltransferase decanoylates Proghrelin
(inferredTo)	[Reaction:R-HSA-422051] Cleavage of the signal peptide of Preproghrelin

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