After phosphorylation on Thr 508, LIMK undergoes homodimerization. Homodimer formation is promoted by the binding of heat shock protein 90 (Hsp90) to a short sequence in the kinase domain of LIMKs. LIMKs are further phosphorylated after homodimer formation and transphosphorylation of the kinase domain.
Bernard, O
Li, R, Soosairajah, J, Harari, D, Citri, A, Price, J, Ng, HL, Morton, CJ, Parker, MW, Yarden, Y, Bernard, O
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