After phosphorylation on Thr 508, LIMK undergoes homodimerization. Homodimer formation is promoted by the binding of heat shock protein 90 (Hsp90) to a short sequence in the kinase domain of LIMKs. LIMKs are further phosphorylated after homodimer formation and transphosphorylation of the kinase domain.
Yarden, Y, Soosairajah, J, Morton, CJ, Harari, D, Li, R, Bernard, O, Parker, MW, Ng, HL, Price, J, Citri, A
Bernard, O
© 2022 Reactome
