Reactome | Dimerization of LIMK1 by Hsp90

Dimerization of LIMK1 by Hsp90

Stable Identifier

R-HSA-419645

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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After phosphorylation on Thr 508, LIMK undergoes homodimerization. Homodimer formation is promoted by the binding of heat shock protein 90 (Hsp90) to a short sequence in the kinase domain of LIMKs. LIMKs are further phosphorylated after homodimer formation and transphosphorylation of the kinase domain.

Literature References

PubMed ID	Title	Journal	Year
16641196	Hsp90 increases LIM kinase activity by promoting its homo-dimerization Yarden, Y, Soosairajah, J, Morton, CJ, Harari, D, Li, R, Bernard, O, Parker, MW, Ng, HL, Price, J, Citri, A	FASEB J	2006
17188549	Lim kinases, regulators of actin dynamics Bernard, O	Int J Biochem Cell Biol	2007