Reactome | ROCK activation by RHO

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ROCK activation by RHO Show undefined attributes

authored	[InstanceEdit:425201] Akkerman, JW, 2009-06-03
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:419048] Jupe, S, 2009-04-28 12:51:40
dbId	419049
displayName	ROCK activation by RHO
edited	[InstanceEdit:421726] Jupe, S, 2009-05-20 09:50:28
eventOf	[Pathway:R-HSA-5627117] RHO GTPases Activate ROCKs - Homo sapiens [Pathway:R-HSA-416572] Sema4D induced cell migration and growth-cone collapse - Homo sapiens [Pathway:R-HSA-416482] G alpha (12/13) signalling events - Homo sapiens
followingEvent	[Reaction:R-HSA-419083] Myosin phosphatase inactivation by ROCK - Homo sapiens [Reaction:R-HSA-419197] Myosin regulatory light chain phosphorylation by ROCK - Homo sapiens [Reaction:R-HSA-419087] LIM kinase phosphorylation by ROCK - Homo sapiens
input	[Complex:R-HSA-419161] RHOA/B/C:GTP [plasma membrane] [DefinedSet:R-HSA-419057] ROCK1,ROCK2 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:421378] The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase [LiteratureReference:5627666] The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton [LiteratureReference:5668833] Arachidonic acid-induced Ca2+ sensitization of smooth muscle contraction through activation of Rho-kinase [LiteratureReference:5668839] Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I [LiteratureReference:5668838] Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	ROCK activation by RHO
orthologousEvent	[Reaction:R-CEL-419049] ROCK activation by RHO - Caenorhabditis elegans [Reaction:R-DME-419049] ROCK activation by RHO - Drosophila melanogaster [Reaction:R-GGA-419049] ROCK activation by RHO - Gallus gallus [Reaction:R-XTR-419049] ROCK activation by RHO - Xenopus tropicalis [Reaction:R-DRE-419049] ROCK activation by RHO - Danio rerio [Reaction:R-SSC-419049] ROCK activation by RHO - Sus scrofa [Reaction:R-BTA-419049] ROCK activation by RHO - Bos taurus [Reaction:R-CFA-419049] ROCK activation by RHO - Canis familiaris [Reaction:R-RNO-419049] ROCK activation by RHO - Rattus norvegicus [Reaction:R-MMU-419049] ROCK activation by RHO - Mus musculus
output	[Complex:R-HSA-422483] Activated ROCK:RhoA/B/C:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-416588] Activation of Rho by LARG and PDZ-RhoGEF - Homo sapiens [Reaction:R-HSA-419166] GEFs activate RhoA,B,C - Homo sapiens [Reaction:R-HSA-442291] VAV2 is a GEF for Rho/Rac family kinases - Homo sapiens [Reaction:R-HSA-442314] VAV3 is a GEF for Rho/Rac family kinases - Homo sapiens
regulatedBy	[NegativeRegulation:9691180] Negative regulation by 'ROCK1,ROCK2:ROCKi [cytosol]'
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:434621] Kumanogoh, A, Kikutani, H, 2009-09-01 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
revised	[InstanceEdit:5668818] Orlic-Milacic, Marija, 2015-01-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-419049
summation	[Summation:420683] ROCKs are primarily known as downstream effectors of RHO, bu...
updateTrackers	[UpdateTracker:9785223] Update Tracker - [Reaction:419049] ROCK activation by RHO - v52:[addLiteratureReference, modifyText] [UpdateTracker:9776913] Update Tracker - [Reaction:419049] ROCK activation by RHO - v74:[addRegulator] [UpdateTracker:9785933] Update Tracker - [Reaction:419049] ROCK activation by RHO - v51:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9785223] Update Tracker - [Reaction:419049] ROCK activation by RHO - v52:[addLiteratureReference, modifyText] [UpdateTracker:9776913] Update Tracker - [Reaction:419049] ROCK activation by RHO - v74:[addRegulator] [UpdateTracker:9785933] Update Tracker - [Reaction:419049] ROCK activation by RHO - v51:[addLiteratureReference]
(hasEvent)	[Pathway:R-HSA-416482] G alpha (12/13) signalling events [Pathway:R-HSA-5627117] RHO GTPases Activate ROCKs [Pathway:R-HSA-416572] Sema4D induced cell migration and growth-cone collapse
(precedingEvent)	[Reaction:R-HSA-419083] Myosin phosphatase inactivation by ROCK [Reaction:R-HSA-419197] Myosin regulatory light chain phosphorylation by ROCK [Reaction:R-HSA-419087] LIM kinase phosphorylation by ROCK

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