Reactome | LIM kinase phosphorylation by ROCK

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LIM kinase phosphorylation by ROCK Show undefined attributes

authored	[InstanceEdit:425201] Akkerman, JW, 2009-06-03
catalystActivity	[CatalystActivity:419084] protein serine/threonine kinase activity of Activated ROCK:RhoA/B/C:GTP [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:419086] Jupe, S, 2009-04-28 12:55:15
dbId	419087
displayName	LIM kinase phosphorylation by ROCK
edited	[InstanceEdit:419086] Jupe, S, 2009-04-28 12:55:15
eventOf	[Pathway:R-HSA-5627117] RHO GTPases Activate ROCKs - Homo sapiens [Pathway:R-HSA-416572] Sema4D induced cell migration and growth-cone collapse - Homo sapiens
inferredFrom	[Reaction:R-NUL-421733] ROCK1 phosphorylates LIMK2 (rat) - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [CandidateSet:R-HSA-419708] LIM Kinases [cytosol]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:420679] Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop [LiteratureReference:420676] Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase [LiteratureReference:434919] Regulation of LIM-kinase 1 and cofilin in thrombin-stimulated platelets
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	LIM kinase phosphorylation by ROCK
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [CandidateSet:R-HSA-419709] p-LIMK [cytosol]
precedingEvent	[Reaction:R-HSA-419049] ROCK activation by RHO - Homo sapiens
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:434621] Kumanogoh, A, Kikutani, H, 2009-09-01 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-419087
summation	[Summation:419713] LIM kinases are serine protein kinases with a unique combina...
updateTrackers	[UpdateTracker:9786850] Update Tracker - [Reaction:419087] LIM kinase phosphorylation by ROCK - v47:[modifyText] [UpdateTracker:9785854] Update Tracker - [Reaction:419087] LIM kinase phosphorylation by ROCK - v51:[modifyText] [UpdateTracker:9785142] Update Tracker - [Reaction:419087] LIM kinase phosphorylation by ROCK - v52:[addLiteratureReference, modifyText] [UpdateTracker:9790648] Update Tracker - [Reaction:419087] LIM kinase phosphorylation by ROCK - v33:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9786850] Update Tracker - [Reaction:419087] LIM kinase phosphorylation by ROCK - v47:[modifyText] [UpdateTracker:9785854] Update Tracker - [Reaction:419087] LIM kinase phosphorylation by ROCK - v51:[modifyText] [UpdateTracker:9785142] Update Tracker - [Reaction:419087] LIM kinase phosphorylation by ROCK - v52:[addLiteratureReference, modifyText] [UpdateTracker:9790648] Update Tracker - [Reaction:419087] LIM kinase phosphorylation by ROCK - v33:[addLiteratureReference]
(hasEvent)	[Pathway:R-HSA-5627117] RHO GTPases Activate ROCKs [Pathway:R-HSA-416572] Sema4D induced cell migration and growth-cone collapse
(inferredTo)	[Reaction:R-NUL-421733] ROCK1 phosphorylates LIMK2 (rat)

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