Reactome | Myosin regulatory light chain phosphorylation by ROCK

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Myosin regulatory light chain phosphorylation by ROCK Show undefined attributes

authored	[InstanceEdit:425201] Akkerman, JW, 2009-06-03
catalystActivity	[CatalystActivity:419084] protein serine/threonine kinase activity of Activated ROCK:RhoA/B/C:GTP [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:419198] Jupe, S, 2009-04-29 13:41:48
dbId	419197
displayName	Myosin regulatory light chain phosphorylation by ROCK
edited	[InstanceEdit:421726] Jupe, S, 2009-05-20 09:50:28
eventOf	[Pathway:R-HSA-5627117] RHO GTPases Activate ROCKs - Homo sapiens [Pathway:R-HSA-416572] Sema4D induced cell migration and growth-cone collapse - Homo sapiens
followingEvent	[Reaction:R-HSA-419232] Myosin phosphatase dephosphorylates myosin regulatory light chain - Homo sapiens
inferredFrom	[Reaction:R-NUL-421724] Myosin regulatory light chain phosphorylation by Rock2 - Gallus gallus
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-419194] Smooth muscle/non-muscle myosin II [cytosol]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:419192] Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase) [LiteratureReference:419187] Regulation of myosin II dynamics by phosphorylation and dephosphorylation of its light chain in epithelial cells [LiteratureReference:435413] Rho-kinase contributes to diphosphorylation of myosin II regulatory light chain in nonmuscle cells [LiteratureReference:5668847] Phosphorylation of smooth muscle myosin at two distinct sites by myosin light chain kinase [LiteratureReference:5668846] Effects of phosphorylation of light chain residues threonine 18 and serine 19 on the properties and conformation of smooth muscle myosin
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Myosin regulatory light chain phosphorylation by ROCK
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-419195] p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol]
precedingEvent	[Reaction:R-HSA-419049] ROCK activation by RHO - Homo sapiens
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:434621] Kumanogoh, A, Kikutani, H, 2009-09-01 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
revised	[InstanceEdit:5668845] Orlic-Milacic, Marija, 2015-01-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-419197
summation	[Summation:419189] Nonmuscle myosin II (NMM2) is an actin-based motor protein t...
updateTrackers	[UpdateTracker:9785050] Update Tracker - [Reaction:419197] Myosin regulatory light chain phosphorylation by ROCK - v52:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9785050] Update Tracker - [Reaction:419197] Myosin regulatory light chain phosphorylation by ROCK - v52:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-5627117] RHO GTPases Activate ROCKs [Pathway:R-HSA-416572] Sema4D induced cell migration and growth-cone collapse
(precedingEvent)	[Reaction:R-HSA-419232] Myosin phosphatase dephosphorylates myosin regulatory light chain
(inferredTo)	[Reaction:R-NUL-421724] Myosin regulatory light chain phosphorylation by Rock2