Reactome | Activation of Rho by LARG and PDZ-RhoGEF

Schema > Reaction > Entries

Activation of Rho by LARG and PDZ-RhoGEF Show undefined attributes

authored	[InstanceEdit:399743] Garapati, P V, 2009-03-23 09:59:28
catalystActivity	[CatalystActivity:416599] guanyl-nucleotide exchange factor activity of SEMA4D:ERBB2:p-Y-PLXNB1:RND1:ARHGEF11,ARHGEF12 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:416590] Garapati, P V, 2009-03-30 15:26:31
dbId	416588
displayName	Activation of Rho by LARG and PDZ-RhoGEF
edited	[InstanceEdit:399760] Garapati, P V, 2009-03-23 10:00:07
eventOf	[Pathway:R-HSA-416572] Sema4D induced cell migration and growth-cone collapse - Homo sapiens
followingEvent	[Reaction:R-HSA-419049] ROCK activation by RHO - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-419164] RhoA,B,C:GDP [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:416578] Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells [LiteratureReference:416551] Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors [LiteratureReference:416592] Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	Activation of Rho by LARG and PDZ-RhoGEF
orthologousEvent	[Reaction:R-CEL-416588] Activation of Rho by LARG and PDZ-RhoGEF - Caenorhabditis elegans [Reaction:R-DME-416588] Activation of Rho by LARG and PDZ-RhoGEF - Drosophila melanogaster [Reaction:R-GGA-416588] Activation of Rho by LARG and PDZ-RhoGEF - Gallus gallus [Reaction:R-XTR-416588] Activation of Rho by LARG and PDZ-RhoGEF - Xenopus tropicalis [Reaction:R-DRE-416588] Activation of Rho by LARG and PDZ-RhoGEF - Danio rerio [Reaction:R-SSC-416588] Activation of Rho by LARG and PDZ-RhoGEF - Sus scrofa [Reaction:R-BTA-416588] Activation of Rho by LARG and PDZ-RhoGEF - Bos taurus [Reaction:R-CFA-416588] Activation of Rho by LARG and PDZ-RhoGEF - Canis familiaris [Reaction:R-RNO-416588] Activation of Rho by LARG and PDZ-RhoGEF - Rattus norvegicus [Reaction:R-MMU-416588] Activation of Rho by LARG and PDZ-RhoGEF - Mus musculus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-419161] RHOA/B/C:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-416594] LARG and PDZ-RhoGEF binds to Plexin-B1 - Homo sapiens
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:434621] Kumanogoh, A, Kikutani, H, 2009-09-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-416588
summation	[Summation:416567] The RhoGEFs LARG and PDZ-RhoGEF complexed with Plexin-B1 sti...

Referrals

(hasEvent)	[Pathway:R-HSA-416572] Sema4D induced cell migration and growth-cone collapse
(precedingEvent)	[Reaction:R-HSA-419049] ROCK activation by RHO