Reactome | Trafficking of GluR2-containing AMPA receptors to synapse

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Trafficking of GluR2-containing AMPA receptors to synapse Show undefined attributes

authored	[InstanceEdit:210542] Mahajan, SS, 2008-01-14 16:01:52
catalystActivity	[CatalystActivity:416995] ATP hydrolysis activity of NSF [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:416984] Mahajan, SS, 2009-04-07 15:17:07
dbId	416985
displayName	Trafficking of GluR2-containing AMPA receptors to synapse
edited	[InstanceEdit:422465] Mahajan, SS, 2009-05-31 11:49:00
eventOf	[Pathway:R-HSA-416993] Trafficking of GluR2-containing AMPA receptors - Homo sapiens
followingEvent	[Reaction:R-HSA-421007] Endocytosis of Ca impermeable AMPA receptors - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-HSA-399713] Ca impermeable AMPA receptors [plasma membrane] [DefinedSet:R-HSA-416631] GRIP1/GRIP2 [plasma membrane] [SimpleEntity:R-ALL-29372] Pi [cytosol] [EntityWithAccessionedSequence:R-HSA-416989] PICK1 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:421008] PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Trafficking of GluR2-containing AMPA receptors to synapse
orthologousEvent	[Reaction:R-MMU-416985] Trafficking of GluR2-containing AMPA receptors to synapse - Mus musculus [Reaction:R-DME-416985] Trafficking of GluR2-containing AMPA receptors to synapse - Drosophila melanogaster [Reaction:R-GGA-416985] Trafficking of GluR2-containing AMPA receptors to synapse - Gallus gallus [Reaction:R-DRE-416985] Trafficking of GluR2-containing AMPA receptors to synapse - Danio rerio [Reaction:R-SSC-416985] Trafficking of GluR2-containing AMPA receptors to synapse - Sus scrofa [Reaction:R-BTA-416985] Trafficking of GluR2-containing AMPA receptors to synapse - Bos taurus [Reaction:R-RNO-416985] Trafficking of GluR2-containing AMPA receptors to synapse - Rattus norvegicus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-HSA-399713] Ca impermeable AMPA receptors [plasma membrane] [DefinedSet:R-HSA-416631] GRIP1/GRIP2 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-416989] PICK1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-416639] Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-8858531] Negative regulation by 'TSPAN7:PICK1 [plasma membrane]'
regulationReference	[RegulationReference:9642553] Negative regulation by 'TSPAN7:PICK1 [plasma membrane]' PICK1 targets activated protein kinase Calpha to AMPA receptor clusters in spines of hippocampal neurons and reduces surface levels of the AMPA-type glutamate receptor subunit 2
releaseDate	2009-06-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:421048] Ziff, EB, 2009-05-15 16:23:37
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-416985
summation	[Summation:421015] Constitutively recycling GluR2 containing AMPA receptors in ... [Summation:8858525] Tetraspanin 7 (TSPAN7) a member of the tetraspanin superfami...
updateTrackers	[UpdateTracker:9783756] Update Tracker - [Reaction:416985] Trafficking of GluR2-containing AMPA receptors to synapse - v56:[addRegulator] [UpdateTracker:9779621] Update Tracker - [Reaction:416985] Trafficking of GluR2-containing AMPA receptors to synapse - v65:[modifyText] [UpdateTracker:9775510] Update Tracker - [Reaction:416985] Trafficking of GluR2-containing AMPA receptors to synapse - v78:[addSummation]

Referrals

(updatedInstance)	[UpdateTracker:9783756] Update Tracker - [Reaction:416985] Trafficking of GluR2-containing AMPA receptors to synapse - v56:[addRegulator] [UpdateTracker:9779621] Update Tracker - [Reaction:416985] Trafficking of GluR2-containing AMPA receptors to synapse - v65:[modifyText] [UpdateTracker:9775510] Update Tracker - [Reaction:416985] Trafficking of GluR2-containing AMPA receptors to synapse - v78:[addSummation]
(hasEvent)	[Pathway:R-HSA-416993] Trafficking of GluR2-containing AMPA receptors
(precedingEvent)	[Reaction:R-HSA-421007] Endocytosis of Ca impermeable AMPA receptors

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