ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link)

Stable Identifier
Reaction [transition]
Homo sapiens
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The alpha-2,6-sialyltransferases 1-6 (ST6GALNAC1-6) are able to transfer a sialic acid (Neu5Ac) moiety to the terminal N-acetylgalactosaminyl (GalNAc-R) residue of O-glycosylated proteins, glycoproteins and some gangliosides. Neu5Ac is added to GalNAc-R via an alpha-2,6 linkage (Ikehara et al. 1999, Samyn-Petit et al, 2000, Harduin-Lepers et al. 2000, Tsuchida et al. 2003, Senda et al. 2007). Once sialylated, glycoconjugates translocate to the plasma membrane by an unknown mechanism. For simplicity, GalNAc-R is shown in a generic form where R represents other sugars O-linked to proteins which can result in a large variability in glycoconjugate structures.
Literature References
PubMed ID Title Journal Year
11062056 Cloning, expression and gene organization of a human Neu5Ac alpha 2-3Gal beta 1-3GalNAc alpha 2,6-sialyltransferase: hST6GalNAcIV

Vallejo-Ruiz, V, Augé, C, Zanetta, JP, Harduin-Lepers, A, Delannoy, P, Samyn-Petit, B, Krzewinski-Recchi, MA, Steelant, WF, Stokes, DC

Biochem J 2000
10742600 Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells

Harduin-Lepers, A, Delannoy, P, Samyn-Petit, B, Krzewinski-Recchi, MA, Steelant, WF

Biochim Biophys Acta 2000
17123352 Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers

Ono, Y, Senda, M, Nakamura, Y, Tsuchida, A, Yoshikawa, K, Hagiwara, T, Katagiri, Y, Ogiso, M, Oshima, S, Kiso, M, Furukawa, K, Urano, T, Furukawa, K, Kasama, K, Kaneda, T, Ito, A

Biochem. J. 2007
12668675 Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides

Yoshida, A, Furukawa, K, Nakamura, Y, Tsuchida, A, Okajima, T, Furukawa, K, Ando, T, Kannagi, R, Ishida, H, Kiso, M

J. Biol. Chem. 2003
10536037 Cloning and expression of a human gene encoding an N-acetylgalactosamine-alpha2,6-sialyltransferase (ST6GalNAc I): a candidate for synthesis of cancer-associated sialyl-Tn antigens

Kono, M, Kojima, N, Tsuda, T, Issiki, S, Kurosawa, N, Tsuji, S, Narimatsu, H, Nishimura, SI, Nishihara, S, Kudo, T, Ikehara, Y, Morozumi, K, Itzkowitz, S

Glycobiology 1999
Catalyst Activity

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity of ST6GALNAC1-6 [Golgi membrane]

Orthologous Events
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