ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues

Stable Identifier
R-HSA-4084978
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The alpha-2,8-sialyltransferases 1-6 (ST8SIA1-6) are involved in the production of gangliosides, glycoproteins and glycolipids. They transfer N-acetylneuraminate (Neu5Ac) to terminal Neu5Ac-yl groups of these glycoconjugates (Nakayama et al. 1996, Scheidegger et al. 1995, Lee et al. 1998, Angata et al. 2001, Kim et al. 1997). Once sialylated, glycoconjugates translocate to the plasma membrane by an unknown mechanism. For simplicity, Neu5Ac-R is shown in a generic form where R represents other sugars O-linked to proteins which can result in a large variability in glycoconjugate structures.

Literature References
PubMed ID Title Journal Year
9199191 Molecular cloning and expression of human alpha2,8-sialyltransferase (hST8Sia V)

Kim, YJ, Kim, KS, Do, S, Kim, CH, Kim, SK, Lee, YC

Biochem. Biophys. Res. Commun. 1997
7559389 A human STX cDNA confers polysialic acid expression in mammalian cells

Scheidegger, EP, Sternberg, LR, Roth, J, Lowe, JB

J. Biol. Chem. 1995
9826427 Cloning and expression of cDNA for a human Sia alpha 2,3Gal beta 1, 4GlcNA:alpha 2,8-sialyltransferase (hST8Sia III)

Lee, YC, Kim, YJ, Lee, KY, Kim, KS, Kim, BU, Kim, HN, Kim, CH, Do, SI

Arch. Biochem. Biophys. 1998
8631981 Expression cloning of a human GT3 synthase. GD3 AND GT3 are synthesized by a single enzyme

Nakayama, J, Fukuda, MN, Hirabayashi, Y, Kanamori, A, Sasaki, K, Nishi, T, Fukuda, M

J. Biol. Chem. 1996
11279095 Unique disulfide bond structures found in ST8Sia IV polysialyltransferase are required for its activity

Angata, K, Yen, TY, El-Battari, A, Macher, BA, Fukuda, M

J. Biol. Chem. 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity of ST8SIA1-6 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created