Rnd1 interacts with Plexin-B1:Sema4D

Stable Identifier
R-HSA-400677
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Rnd1 is constitutively active and stably associates with Plexin-B1 and regulates the R-Ras GAP activity of the C1 and C2 domains of the Plexin-B1 cytoplasmic tail. These domains interact with each other and in this closed conformation cannot associate with active R-Ras-GTP. Rnd1 binds to the region between C1 and C2 domains and disrupts this interaction, allowing the receptor to associate with GTP-bound R-Ras.

Literature References
PubMed ID Title Journal Year
12730235 Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells

Oinuma, I, Katoh, H, Harada, A, Negishi, M

J Biol Chem 2003
Participants
Participant Of
Orthologous Events
Authored
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Created