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Rnd1 interacts with Plexin-B1:Sema4D
Stable Identifier
R-HSA-400677
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Semaphorin interactions (Homo sapiens)
Sema4D in semaphorin signaling (Homo sapiens)
Sema4D mediated inhibition of cell attachment and migration (Homo sapiens)
Rnd1 interacts with Plexin-B1:Sema4D (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Rnd1 is constitutively active and stably associates with Plexin-B1 and regulates the R-Ras GAP activity of the C1 and C2 domains of the Plexin-B1 cytoplasmic tail. These domains interact with each other and in this closed conformation cannot associate with active R-Ras-GTP. Rnd1 binds to the region between C1 and C2 domains and disrupts this interaction, allowing the receptor to associate with GTP-bound R-Ras.
Literature References
PubMed ID
Title
Journal
Year
12730235
Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells
Katoh, H
,
Oinuma, I
,
Negishi, M
,
Harada, A
J Biol Chem
2003
Participants
Input
RND1:GTP [plasma membrane]
(Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1 [plasma membrane]
(Homo sapiens)
Output
SEMA4D:MET:p-Y-PLXNB1:RND1:GTP [plasma membrane]
(Homo sapiens)
Participates
as an event of
Sema4D mediated inhibition of cell attachment and migration (Homo sapiens)
Orthologous Events
Rnd1 interacts with Plexin-B1:Sema4D (Bos taurus)
Rnd1 interacts with Plexin-B1:Sema4D (Canis familiaris)
Rnd1 interacts with Plexin-B1:Sema4D (Gallus gallus)
Rnd1 interacts with Plexin-B1:Sema4D (Mus musculus)
Rnd1 interacts with Plexin-B1:Sema4D (Rattus norvegicus)
Rnd1 interacts with Plexin-B1:Sema4D (Sus scrofa)
Rnd1 interacts with Plexin-B1:Sema4D (Xenopus tropicalis)
Authored
Garapati, P V (2009-03-23)
Reviewed
Kikutani, H (2009-09-02)
Kumanogoh, A (2009-09-02)
Created
Garapati, P V (2009-03-24)
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