Reactome | Negative gene expression regulation by 'NR1D1:heme:Corepressors:ARNTL gene [nucleoplasm]' Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta

Schema > RegulationReference > Entries

created	[InstanceEdit:9641190] Wu, G, 2019-04-04
dbId	9643028
displayName	Negative gene expression regulation by 'NR1D1:heme:Corepressors:ARNTL gene [nucleoplasm]' Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta
literatureReference	[LiteratureReference:549530] Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta [LiteratureReference:549356] Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock [LiteratureReference:549400] The orphan nuclear receptor Rev-erbalpha recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene [LiteratureReference:1368128] Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways
regulatedBy	[NegativeGeneExpressionRegulation:R-HSA-421342] Negative gene expression regulation by 'NR1D1:heme:Corepressors:ARNTL gene [nucleoplasm]'
schemaClass	RegulationReference

(regulationReference)

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