Protein kinase C, alpha type phosphorylates MARCKS

Stable Identifier
R-HSA-399978
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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One of the known targets of PKC-alpha is the Myristoylated Alanine-rich C Kinase Substrate (MARCKS). MARCKS is phosphorylated at 4 serine residues and is believed to affect trafficking of insulin granules, increasing insulin secretion.
Literature References
PubMed ID Title Journal Year
8132675 Protein kinase C-mediated phosphorylation and calmodulin binding of recombinant myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein

Stumpo, DJ, Haupt, DM, Vasulka, C, Verghese, GM, Blackshear, PJ, Johnson, JD

J Biol Chem 1994
9808756 The antibody specific for myristoylated alanine-rich C kinase substrate phosphorylated by protein kinase C: activation of protein kinase C in smooth muscle cells in human coronary arteries

Oishi, Y, Miyamoto, E, Ogata, N, Kugiyama, K, Matsumura, T, Yamamoto, H, Yasue, H

Arch Biochem Biophys 1998
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks

Mann, M, Mortensen, P, Olsen, JV, Macek, B, Gnad, F, Blagoev, B, Kumar, C

Cell 2006
7989336 Specificity of the high affinity interaction of protein kinase C with a physiological substrate, myristoylated alanine-rich protein kinase C substrate

Osada, S, Ohno, S, Owada, MK, Fujise, A, Shimizu, N, Takayanagi, A, Hirai, S, Mizuno, K, Nakajima, H, Ueda, Y

J Biol Chem 1994
11588141 Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function

Gilon, P, Henquin, JC

Endocr Rev 2001
1527003 Glucose-induced phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in isolated rat pancreatic islets

Ganesan, S, Smallwood, JI, Rasmussen, H, Calle, R

J Biol Chem 1992
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of Protein Kinase C, alpha type: DAG [plasma membrane]

Orthologous Events
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