Protein kinase C, alpha type phosphorylates MARCKS

Stable Identifier
R-HSA-399978
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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One of the known targets of PKC-alpha is the Myristoylated Alanine-rich C Kinase Substrate (MARCKS). MARCKS is phosphorylated at 4 serine residues and is believed to affect trafficking of insulin granules, increasing insulin secretion.

Literature References
PubMed ID Title Journal Year
9808756 The antibody specific for myristoylated alanine-rich C kinase substrate phosphorylated by protein kinase C: activation of protein kinase C in smooth muscle cells in human coronary arteries

Yamamoto, H, Matsumura, T, Kugiyama, K, Oishi, Y, Ogata, N, Yasue, H, Miyamoto, E

Arch Biochem Biophys 1998
8132675 Protein kinase C-mediated phosphorylation and calmodulin binding of recombinant myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein

Verghese, GM, Johnson, JD, Vasulka, C, Haupt, DM, Stumpo, DJ, Blackshear, PJ

J Biol Chem 1994
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks

Olsen, JV, Blagoev, B, Gnad, F, Macek, B, Kumar, C, Mortensen, P, Mann, M

Cell 2006
7989336 Specificity of the high affinity interaction of protein kinase C with a physiological substrate, myristoylated alanine-rich protein kinase C substrate

Fujise, A, Mizuno, K, Ueda, Y, Osada, S, Hirai, S, Takayanagi, A, Shimizu, N, Owada, MK, Nakajima, H, Ohno, S

J Biol Chem 1994
11588141 Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function

Gilon, P, Henquin, JC

Endocr Rev 2001
1527003 Glucose-induced phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in isolated rat pancreatic islets

Calle, R, Ganesan, S, Smallwood, JI, Rasmussen, H

J Biol Chem 1992
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of Protein Kinase C, alpha type: DAG [plasma membrane]
Physical Entity
Activity
Orthologous Events
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