Reactome | Protein kinase C, alpha type phosphorylates MARCKS

Protein kinase C, alpha type phosphorylates MARCKS

Stable Identifier

R-HSA-399978

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Protein kinase C, alpha type phosphorylates MARCKS

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One of the known targets of PKC-alpha is the Myristoylated Alanine-rich C Kinase Substrate (MARCKS). MARCKS is phosphorylated at 4 serine residues and is believed to affect trafficking of insulin granules, increasing insulin secretion.

Literature References

PubMed ID	Title	Journal	Year
8132675	Protein kinase C-mediated phosphorylation and calmodulin binding of recombinant myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein Verghese, GM, Johnson, JD, Vasulka, C, Haupt, DM, Stumpo, DJ, Blackshear, PJ	J Biol Chem	1994
9808756	The antibody specific for myristoylated alanine-rich C kinase substrate phosphorylated by protein kinase C: activation of protein kinase C in smooth muscle cells in human coronary arteries Yamamoto, H, Matsumura, T, Kugiyama, K, Oishi, Y, Ogata, N, Yasue, H, Miyamoto, E	Arch Biochem Biophys	1998
17081983	Global, in vivo, and site-specific phosphorylation dynamics in signaling networks Olsen, JV, Blagoev, B, Gnad, F, Macek, B, Kumar, C, Mortensen, P, Mann, M	Cell	2006
7989336	Specificity of the high affinity interaction of protein kinase C with a physiological substrate, myristoylated alanine-rich protein kinase C substrate Fujise, A, Mizuno, K, Ueda, Y, Osada, S, Hirai, S, Takayanagi, A, Shimizu, N, Owada, MK, Nakajima, H, Ohno, S	J Biol Chem	1994
11588141	Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function Gilon, P, Henquin, JC	Endocr Rev	2001
1527003	Glucose-induced phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in isolated rat pancreatic islets Calle, R, Ganesan, S, Smallwood, JI, Rasmussen, H	J Biol Chem	1992