UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
UBC9 and PIAS1 SUMOylate FOXL2 with SUMO1 (Kuo et al. 2009, Marongiu et al 2010, Georges et al. 2011). This modification changes its cellular localization, stability and transcriptional activity (Marongiu et al, 2010). SUMOylation localizes FOXL2 to PML bodies in the nucleus. SUMOylation is required for repression of transcription by FOXL2 at the StAR promoter and reduces transactivation by FOXL2 at the PER2 promoter. Hypophosphorylation of serine-33 correlates with SUMOylation and stablization of FOXL2, leading to enhanced transcriptional activation of TNF-R1, FAS, caspase 8, p21, and aromatase (Kim et al. 2014).
Literature References
PubMed ID Title Journal Year
20209145 The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity

Schlessinger, D, Crisponi, L, Deiana, M, Cao, A, Puddu, A, Meloni, A, Marongiu, M, Marcia, L

PLoS ONE 2010
19744555 Sumoylation of forkhead L2 by Ubc9 is required for its activity as a transcriptional repressor of the Steroidogenic Acute Regulatory gene

Barlow, GM, Bentsi-Barnes, IK, Bae, J, Kuo, FT, Pisarska, MD

Cell. Signal. 2009
24390485 FOXL2 posttranslational modifications mediated by GSK3β determine the growth of granulosa cell tumours

Kim, YH, Lee, K, Ha, NC, Park, M, Park, HO, Bae, J, Kim, HM, Kim, TH, Kim, JH

Nat Commun 2014
22022399 SUMOylation of the Forkhead transcription factor FOXL2 promotes its stabilization/activation through transient recruitment to PML bodies

Crisponi, L, Dipietromaria, A, L'Hôte, D, Todeschini, AL, Georges, A, Marongiu, M, Auer, J, Benayoun, BA, Veitia, RA

PLoS ONE 2011
Catalyst Activity

SUMO transferase activity of UBE2I,PIAS1 [nucleoplasm]

Orthologous Events
Cite Us!