Reactome | Activation of EPH receptors triggers the local activation of...

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created	[InstanceEdit:3928288] Garapati, P V, 2013-07-22
dbId	3928285
displayName	Activation of EPH receptors triggers the local activation of...
literatureReference	[LiteratureReference:3928096] EphA8-ephrinA5 signaling and clathrin-mediated endocytosis is regulated by Tiam-1, a Rac-specific guanine nucleotide exchange factor [LiteratureReference:3928055] Interaction between Tiam1 and the Arp2/3 complex links activation of Rac to actin polymerization [LiteratureReference:4093243] Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2
modified	[InstanceEdit:4640880] Garapati, P V, 2013-09-27
schemaClass	Summation
text	Activation of EPH receptors triggers the local activation of T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1) and this in turn activates RAC1 (Yoo et al. 2010). RAC1 signaling is positively linked to EPH:ephrin (EFN) internalization but the exact link to clathrin endocytosis machinery remains unclear. TIAM1 co-localizes with the ARP2/3 complex at sites of actin polymerization. RAC1 activated by TIAM1 then subsequently activates the ARP2/3 complex proteins leading to actin polymerization (Ten Klooster et al. 2006).

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